Involvement of the muscarinic acetylcholine receptor in inhibition of cell migration

Biochemical Pharmacology

Volumn 63, Issue 4, 2002, Pages 597-605

  Varker, Kimberly A ^a   Williams, Carol L ^a  

^a GUTHRIE RESEARCH INSTITUTE   (United States)

Author keywords

Calphostin C; Cell adhesion; Cell detachment; Cell migration; Chelerythrine; Go6976; Muscarinic acetylcholine receptor; Protein kinase C isoforms

Indexed keywords

12 (2 CYANOETHYL) 6,7,12,13 TETRAHYDRO 13 METHYL 5 OXOINDOLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE; CALCIUM ION; CALPHOSTIN C; CARBACHOL; CHELERYTHRINE; COLLOIDAL GOLD; FIBRONECTIN; INTEGRIN; MAGNESIUM ION; MUSCARINIC RECEPTOR; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C;

ANIMAL CELL; ARTICLE; CELL ADHESION; CELL MIGRATION; CELL SPREADING; CELL STRUCTURE; CHELATION; CHO CELL; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVATION; ENZYME INACTIVATION; MICROSCOPY; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; CARBACHOL; CELL ADHESION; CELL MOVEMENT; CHO CELLS; CHOLINERGIC AGONISTS; CRICETINAE; DOSE-RESPONSE RELATIONSHIP, DRUG; FIBRONECTINS; HUMANS; ISOENZYMES; PROTEIN KINASE C; RECEPTORS, MUSCARINIC; TETRADECANOYLPHORBOL ACETATE; TRANSFECTION;

EID: 0037085006     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(01)00901-7     Document Type: Article

References (34)

1. Chemokines and their role in tumor growth and metastasis
2. Cell migration: A physically integrated process
3. Role of protein kinase C in attachment, spreading, and migration of human endothelial cells
4. Basic science of small cell lung cancer
5. Identification of G protein-coupled receptors potently stimulating migration of human transitional-cell carcinoma cells
6. Lysophosphatidic acid and sphingosine 1-phosphate stimulate endothelial cell wound healing
7. Sphingolipid receptor signaling and function in human bladder carcinoma cells: Inhibition of LPA but enhancement of thrombin-stimulated motility
8. i-coupled surface receptor. Potential involvement in angiogenesis
9. Comparison of intrinsic activities of the putative sphingosine 1-phosphate receptor subtypes to regulate several signaling pathways in their cDNA-transfected Chinese hamster ovary cells
10. αi-coupled receptors
11. s
12. G protein-coupled receptors in vascular smooth muscle cells
13. Adenosine receptor mediates motility in human melanoma cells
14. Integrin and cadherin synergy regulates contact inhibition of migration and motile activity
15. Regulation of integrin-mediated adhesion during cell migration
16. 1 integrin-mediated cell spreading on fibronectin
17. Protein kinase C regulates integrin-induced activation of the extracellular regulated kinase pathway upstream of Shc
18. Migration of retinal pigment epithelial cells in vitro is regulated by protein kinase C
19. Muscarinic receptors - Characterization, coupling, and function
20. Muscarinic acetylcholine receptors: Signal transduction through multiple effectors
21. 3 muscarinic acetylcholine receptors regulate cytoplasmic myosin by a process involving RhoA and requiring conventional protein kinase C isoforms
22. Regulation of integrin-mediated adhesion by muscarinic acetylcholine receptors and protein kinase C in small cell lung carcinoma
23. Selective inhibition of protein kinase isozymes by the indolocarbazole Go6976
24. Calphostin C (UCN-1028C), a novel microbial compound, is a highly potent and specific inhibitor of protein kinase C
25. Regulation of cell migration by the calcium-dependent protease calpain
26. Physical and biochemical regulation of integrin release during rear detachment of migrating cells
27. Cell motility assay and inhibition by Rho-GDP dissociation inhibitor
28. Chelerythrine is a potent and specific inhibitor of protein kinase C
29. 1
30. 3 muscarinic acetylcholine receptors induces cell-cell adhesion of Chinese hamster ovary cells expressing endogenous cadherins
31. Fibronectin regulates assembly of actin filaments and focal contacts in cultured cells via the heparin-binding site in repeat III13
32. Vascular endothelial growth factor-induced endothelial cell migration and proliferation depend on a nitric oxide-mediated decrease in protein kinase C-δ activity
33. Enhancement of migration by protein kinase C-α and inhibition of proliferation and cell cycle progression by protein kinase C-δ in capillary endothelial cells
34. PKC-α regulates β1-integrin-dependent cell motility through association and control of integrin traffic