Roles of protein kinase C and α-tocopherol in regulation of signal transduction for GATA-4 phosphorylation in HL-1 cardiac muscle cells

Free Radical Biology and Medicine

Volumn 32, Issue 4, 2002, Pages 341-349

  Clément, Sophie A ^a   Tan, Chia Chi ^a   Guo, Jianli ^a   Kitta, Kazumi ^a   Suzuki, Yuichiro J ^a  

^a TUFTS UNIVERSITY   (United States)

Author keywords

Antioxidants; Endothelin; Free radicals; Heart; Mitogen activated protein kinase; PMA; Protein kinase C; Vitamin E

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; ALPHA TOCOPHEROL; CALPHOSTIN C; CHELERYTHRINE; MITOGEN ACTIVATED PROTEIN KINASE; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE; PROTEIN KINASE C; TRANSCRIPTION FACTOR GATA 4; ALKALOID; BENZOPHENANTHRIDINE DERIVATIVE; DNA BINDING PROTEIN; ENZYME INHIBITOR; FREE RADICAL; NAPHTHALENE DERIVATIVE; PHENANTHRIDINE DERIVATIVE; TRANSCRIPTION FACTOR;

ANIMAL CELL; ARTICLE; CELL LINE; CONTROLLED STUDY; DOWN REGULATION; DRUG ACTIVITY; DRUG POTENCY; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME REGULATION; HEART MUSCLE CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; ANIMAL; CELL CULTURE; CYTOLOGY; HEART MUSCLE; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; TIME; WESTERN BLOTTING;

ALPHA-TOCOPHEROL; ANIMAL; BLOTTING, WESTERN; CELL LINE; CELLS, CULTURED; DNA-BINDING PROTEINS; DOWN-REGULATION; ENZYME INHIBITORS; FREE RADICALS; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; MYOCARDIUM; NAPHTHALENES; PHENANTHRIDINES; PHOSPHORYLATION; PROTEIN KINASE C; SIGNAL TRANSDUCTION; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, NON-P.H.S.; TIME FACTORS; TRANSCRIPTION FACTORS; ALKALOIDS; ANIMALS; BENZOPHENANTHRIDINES; GATA4 TRANSCRIPTION FACTOR;

EID: 0037082354     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5849(01)00802-4     Document Type: Article

References (30)

1. Endothelin-1 induces phosphorylation of GATA-4 transcription factor in HL-1 atrial-muscle cell line
2. GATA transcription factors and cardiac development
3. The zinc finger-containing transcription factors GATA-4, -5, and -6. Ubiquitously expressed regulators of tissue-specific gene expression
4. 1a receptor gene expression in the heart: AP-1 and GATA-4 participate in the response to pressure overload
5. Transcription factor GATA-4 regulates cardiac muscle-specific expression of the alpha-myosin heavy-chain gene
6. In vivo analysis of the murine β-myosin heavy chain gene promoter
7. Functional identification of the transcriptional regulatory elements within the promoter region of the human ventricular myosin alkali light chain gene
8. A calcineurin-dependent transcriptional pathway for cardiac hypertrophy
9. Phosphorylation of GATA-4 is involved in α 1-adrenergic agonist-responsive transcription of the endothelin-1 gene in cardiac myocytes
10. Pathophysiology of endothelin in the cardiovascular system
11. First proof that vitamin E is major lipid-soluble, chain-breaking antioxidant in human blood plasma
12. Inhibition of cell proliferation by α-tocopherol. Role of protein kinase C
13. The effect of α-tocopherol on the synthesis, phosphorylation, and activity of protein kinase C in smooth muscle cells after phorbol 12-myristate 13-acetate downregulation
14. Alpha-tocopherol specifically inactivates cellular protein kinase C α by changing its phosphorylation state
15. Molecular mechanisms of myocardial remodeling
16. HL-1 cells: A cardiac muscle cell line that contracts and retains phenotypic characteristics of the adult cardiomyocyte
17. Serotonin stimulates mitogen-activated protein kinase activity through the formation of superoxide anion
18. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
19. PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo
20. Endothelin-dependent actions in cultured AT-1 cardiac myocytes. The role of the epsilon isoform of protein kinase C
21. New insights into the regulation of protein kinase C and novel phorbol ester receptors
22. Myocyte proliferation in end-stage cardiac failure in humans
23. Heart regeneration in adult MRL mice
24. Overexpression of angiotensin II type I receptor in cardiomyocytes induces cardiac hypertrophy and remodeling
25. Genomic organization, promoter analysis, and chromosome localization of the mouse bcl-x gene
26. Mouse GATA-4: A retinoic acid-inducible GATA-binding transcription factor expressed in endodermally derived tissues and heart
27. RasGRP, a Ras guanyl nucleotide-releasing protein with calcium- and diacylglycerol-binding motifs
28. Close similarity of baculovirus-expressed n-chimaerin and protein kinase C α as phorbol ester receptors
29. The guanine nucleotide exchange factor RasGRP is a high-affinity target for diacylglycerol and phorbol esters
30. Cellular and molecular biology of vascular smooth muscle cells in pulmonary hypertension