Cyclic AMP-dependent Cl secretion is regulated by multiple phosphodiesterase subtypes in human colonic epithelial cells

Journal of Membrane Biology

Volumn 185, Issue 2, 2002, Pages 137-144

  O'Grady, S M ^a,b   Jiang, X ^a,b   Maniak, P J ^a,b   Birmachu, W ^a,b   Scribner, L R ^a,b   Bulbulian, B ^a,b   Gullikson, G W ^a,b  

^a UNIVERSITY OF MINNESOTA   (United States)

^b 3M COMPANY   (United States)

Author keywords

Bumetanide; CFTR; Na K 2Cl cotransport; PDE; T84 cells

Indexed keywords

BUMETANIDE; CILOSTAMIDE; CYCLIC AMP; CYCLIC GMP; GLIBENCLAMIDE; ISOBUTYLMETHYLXANTHINE; MILRINONE; PHOSPHODIESTERASE; PHOSPHODIESTERASE INHIBITOR; PICLAMILAST;

ARTICLE; CHLORIDE TRANSPORT; COLON MUCOSA; CYTOSOL; ENZYME INHIBITION; ENZYME REGULATION; HUMAN; HUMAN CELL; HYDROLYSIS; ION EXCHANGE CHROMATOGRAPHY; MEMBRANE CURRENT; MEMBRANE FILTER;

ANIMALS; BUMETANIDE; CATTLE; CHLORIDE CHANNELS; CHLORIDES; CHROMATOGRAPHY, ION EXCHANGE; COLON; CYCLIC AMP; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; ELECTRIC CONDUCTIVITY; GLYBURIDE; HUMANS; INTESTINAL MUCOSA; PATCH-CLAMP TECHNIQUES; PHOSPHODIESTERASE INHIBITORS; PHOSPHORIC DIESTER HYDROLASES;

EID: 0037081021     PISSN: 00222631     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00232-001-0120-3     Document Type: Article

References (29)

1. Chloride channels in the apical membrane of normal and cystic fibrosis airway and intestinal epithelia
2. Selective type IV phosphodiesterase inhibitors as antiasthmatic agents. The syntheses and biological activities of 3-(cyclopentyloxy)-4-methoxybenzamides and analogues
3. Multiple cyclic nucleotide phosphodiesterases
4. Cyclic nucleotide phosphodiesterases: Functional implications of multiple isoforms
5. Identification of conserved domain among cyclic nucleotide phosphodiesterases from diverse species
6. 2+ in Cl secreting epithelial cells
7. Structure, localization and regulation of cGMP-inhibited phosphodiesterase (PDE3)
8. Cyclic nucleotide phosphodiesterase in human bronchial epithelial cells: Characterization of Isoenzymes and functional effects of PDE inhibitors
9. Vasoactive intestinal polypeptide-induced chloride secretion by a colonic epithelial cell line. Direct participation of a basolaterally localized Na-K-Cl cotransport system
10. A human colonic tumor cell line that maintains vectorial electrolyte transport
11. Zinc interactions and conserved motifs of the cGMP-binding cGMP-specific phosphodiesterase suggest that it is a zinc hydrolase
12. Purification of cGMP-binding protein phosphodiesterase from rat lung
13. Cyclic nucleotide phosphodiesterases: Relating structure and function
14. Cloning and characterization of two splice variants of human phosphodiesterase 1A
15. 2+ transients
16. 2+ channels by beta-adrenergic agonists
17. CFTR chloride permeability is regulated by type III phosphodiesterase in airway epithelial cells
18. Signal flow in visual transduction
19. Substituted carbostyrils as inhibitors of cyclic AMP phosphodiesterase
20. Characterization of a cyclic AMP-activated Cl-transport pathway in the apical membrane of a human colonic epithelial cell line
21. 2+ inhibition of VIP and A23187-stimulated Cl secretion by T84 cell monolayers
22. m, rolipram-sensitive, cAMP-specific phosphodiesterase from human brain. Cloning and expression of cDNA, biochemical characterization of recombinant protein and tissue distribution of mRNA
23. Subtypes of the type 4 cAMP phosphodiesterases: Structure, regulation and selective inhibition
24. Engineered deletion of the unique N-terminal domain of the cyclic AMP-specific phosphodiesterase RD1 prevents plasma membrane association and the attainment of the enhanced thermostability without altering its sensitivity to inhibition by rolipram
25. Mechanism of glibenclamide inhibition of cystic fibrosis transmembrane conductance regulator Cl channels expressed in a murine cell line
26. Regulation of cAMP and cGMP signaling: New phosphodiesterases and new functions
27. Molecular cloning of a cDNA encoding the "61kDa" calmodulin-stimulated cyclic nucleotide phosphodiesterase. Tissue-specific expression of structurally related isoforms
28. Cyclic GMP phosphodiesterase inhibitors. 2. Requirement of 6-substitution of quinazoline derivatives for potent and selective inhibitory activity
29. Phosphodiesterase expression in human epithelial cells