A concise and regioselective synthesis of 1-alkyl-4-imidazolecarboxylates

Organic Letters

Volumn 4, Issue 23, 2002, Pages 4133-4134

  Helal, Christopher J ^a   Lucas, John C ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYLIC ACID; DYES, REAGENTS, INDICATORS, MARKERS AND BUFFERS; IMIDAZOLE DERIVATIVE;

ALKYLATION; ARTICLE; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ALKYLATION; CARBOXYLIC ACIDS; IMIDAZOLES; INDICATORS AND REAGENTS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037078851     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol026892k     Document Type: Article

References (15)

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11. 3, 400 MHz): δ 7.18 (s, 1H), 4.21 (q, J = 7.1 Hz, 2H), 3.4-2.9 (brs, 6H), 1.30 (t, J = 7.1 Hz, 3H).
12. For other chemistry using ethyl 3-N,N-(dimethylamino)-2-isocyanoacrylate (1) in heterocycle synthesis, see: (a) Lau, H.; Schollkopf, U. Liebegs Ann. Chem. 1982, 2093-2095.
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14. For an example of a related 1-heteroaryl-4-imidazolecarboxylate synthesis, see: Selic, L.; Stanovnik, B. J. Heterocycl. Chem. 1998, 35, 1527-1529.
15. + found, 231.1