Designing analogues of mini atrial natriuretic peptide based on structural analysis by NMR and restrained molecular dynamics

Journal of Medicinal Chemistry

Volumn 45, Issue 4, 2002, Pages 881-887

  Sugase, Kenji ^a,b   Oyama, Yoshiaki ^c   Kitano, Katsuhiko ^c   Iwashita, Takashi ^a   Fujiwara, Toshimichi ^b,d   Akutsu, Hideo ^b,d   Ishiguro, Masaji ^a  

^a SUNTORY INSTITUTE FOR BIOORGANIC RESEARCH   (Japan)

^b YOKOHAMA NATIONAL UNIVERSITY   (Japan)

^c SUNTORY LTD   (Japan)

^d OSAKA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

(DEXTRO ALANINE 5 DEXTRO ALANINE 6)MINI ATRIAL NATRIURETIC PEPTIDE; (DEXTRO ALANINE 5)MINI ATRIAL NATRIURETIC PEPTIDE; (DEXTRO ALANINE 6)MINI ATRIAL NATRIURETIC PEPTIDE; ATRIAL NATRIURETIC FACTOR DERIVATIVE; GLYCINE; ISOLEUCINE; MINI ATRIAL NATRIURETIC PEPTIDE DERIVATIVE; PHENYLALANINE; UNCLASSIFIED DRUG;

AMINO ACID ANALYSIS; ANIMAL CELL; ARTICLE; COMPUTER SIMULATION; DRUG ACTIVITY; DRUG CONFORMATION; DRUG DESIGN; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; MOLECULAR DYNAMICS; MOLECULAR MODEL; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PEPTIDE ANALYSIS; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; ATRIAL NATRIURETIC FACTOR; CHO CELLS; CRICETINAE; CYCLIC AMP; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; OLIGOPEPTIDES; PEPTIDES, CYCLIC; PROTEIN CONFORMATION; SOLUTIONS;

EID: 0037075127     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm010106k     Document Type: Article

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