Experimental identification of downhill protein folding

Science

Volumn 298, Issue 5601, 2002, Pages 2191-2195

  Garcia Mira, Maria M ^a,b,c   Sadqi, Mourad ^a   Fischer, Niels ^a   Sanchez Ruiz, Jose M ^b   Muñoz, Victor ^a  

^a UNIVERSITY OF MARYLAND   (United States)

^b UNIVERSITY OF GRANADA   (Spain)

^c UNIVERSITY OF BAYREUTH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CALORIMETRY; ESCHERICHIA COLI; SPECTROSCOPIC ANALYSIS; STATISTICAL METHODS; STRUCTURE (COMPOSITION);

PROTEIN FOLDING;

ENZYMES;

BACTERIAL ENZYME; BACTERIAL PROTEIN; OXOGLUTARATE DEHYDROGENASE; PROTEIN BBL; PROTEIN DOWNHILL; UNCLASSIFIED DRUG;

PROTEIN;

ARTICLE; CALORIMETRY; ESCHERICHIA COLI; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN STRUCTURE; SPECTROSCOPY;

ACYLTRANSFERASES; CALORIMETRY, DIFFERENTIAL SCANNING; CIRCULAR DICHROISM; ESCHERICHIA COLI; FLUORESCENCE; FLUORESCENCE RESONANCE ENERGY TRANSFER; HYDROGEN-ION CONCENTRATION; KETOGLUTARATE DEHYDROGENASE COMPLEX; MODELS, CHEMICAL; MODELS, MOLECULAR; MULTIENZYME COMPLEXES; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN DENATURATION; PROTEIN FOLDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PROTEIN SUBUNITS; TEMPERATURE; THERMODYNAMICS;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; NEGIBACTERIA;

EID: 0037073934     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1077809     Document Type: Article

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36. We thank B. Ibarra-Molero for collaborating in the data analysis and G. Lorimer for helpful suggestions on the manuscript V.M. is a recipient of a Dreyfus New Faculty Award, a Packard Fellowship for Science and Engineering, and a Searle Scholar Award. The research described in this article has been supported in part by grant 36601-AC4 from the Petrol Research Fund (V.M.) and grant BIO2000-1437 from the Spanish Ministry of Science and Technology (J.M.S.R.).