Comparison between liquid chromatography-UV detection and liquid chromatography-mass spectrometry for the characterization of impurities and/or degradants present in trimethoprim tablets

Journal of Chromatography A

Volumn 970, Issue 1-2, 2002, Pages 141-154

  Barbarin, Nicolas ^a   Henion, Jack D ^a   Wu, Yunhui ^b  

^a Department of Obstetrics Gynecology   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Component detection algorithm; Contour chromatogram algorithm; Mass spectrometry; Trimethoprim; UV detection

Indexed keywords

ALGORITHMS; ATMOSPHERIC PRESSURE; COMPUTER SOFTWARE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IMPURITIES; IONIZATION OF SOLIDS; MASS SPECTROMETRY; ULTRAVIOLET DETECTORS;

DRUG DEVELOPMENT PROCESS;

DRUG PRODUCTS;

TRIMETHOPRIM;

ALGORITHM; ARTICLE; ATMOSPHERIC PRESSURE; COMPUTER PROGRAM; DRUG DETERMINATION; DRUG IMPURITY; DRUG MANUFACTURE; DRUG PURITY; INTERMETHOD COMPARISON; IONIZATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MOLECULAR WEIGHT; NOISE; PRIORITY JOURNAL; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; TABLET; ULTRAVIOLET RADIATION;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG CONTAMINATION; MASS SPECTROMETRY; SPECTROPHOTOMETRY, ULTRAVIOLET; TABLETS; TRIMETHOPRIM;

EID: 0037073080     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0021-9673(02)01035-X     Document Type: Article

References (19)

1. ICH . International Conference on Harmonization Guideline. Q3A: impurities in new drug substances. 1995.
2. ICH . International Conference on Harmonization Guideline. Q3B: impurities in new drug products. 1996.
3. ICH . International Conference on Harmonization Guideline. Draft Consensus Guideline: impurities in new drug substances. 1999.
4. McCrossen S.D., Bryant D.K., Cook B.R. J. Pharm. Biomed. Anal. 17:1998;455.
5. Martindale's . The Extra Pharmacopia. 27th ed:1979;Pharmaceutical Press, London. 361.
6. Bergh J.J., Breytenbach J.C. J. Chromatogr. 387:1987;528.
7. Bergh J.J., Breytenbach J.C., Wessels P.L. J. Pharm. Sci. 78:(4):1989;348.
8. Bergh J.J., Breytenbach J.C., Du Preez J.L. J. Chromatogr. 513:1990;392.
9. Dedola G., Fasani E., Albini A. J. Photochem. Photobiol. A. 123:1999;47.
10. Lehr G.J., Barry T.L., Petzinger G., Hanna G.M., Zito S.W. J. Pharm. Biomed. Anal. 19:1999;373.
11. Nachilobe P., Boison J.O., Cassidy R.M., Fesser A.C.E. J. Chromatogr. 616:1993;243.
12. Cannavan A., Hewitt S.A., Floyd S.D., Kennedy D.G. Analyst. 122:1997;1379.
13. De Baere S., Baert K., Croubels S., De Busser J., De Wasch K., De Backer P. Analyst. 125:2000;409.
14. Hirch R., Ternes T.A., Haberer K., Mehlich A., Ballwanz F., Kratz K.-L. J. Chromatogr. A. 815:1998;213.
15. Windig W., Phalp J.M., Payne A.W. Anal. Chem. 68:1996;3602.
16. De Martilis F., Ciranni-Signoretti E., De Marchi G., Lunardelli M., Sekules G., Zanotti-Gerosa A. Boll. Chim. Farm. 122:1983;462.
17. Duffin K.L., Wachs T., Henion J.D. Anal. Chem. 64:1992;61.
18. Seto C., Grosset J.S., Waddell D.S., Curtis J.M., Boyd R.K. J. Am. Soc. Mass Spectrom. 12:2001;571.
19. Hevko J.M., Murphy C. J. Am. Soc. Mass Spectrom. 12:2001;763.