Melatonin microinjection into the medial preoptic area increases sleep in the rat

Life Sciences

Volumn 71, Issue 17, 2002, Pages 2067-2070

  Mendelson, Wallace B ^a,b  

^a UNIVERSITY OF CHICAGO   (United States)

^b NONE   (United States)

Author keywords

Hypothalamus; Melatonin; Pentobarbital; Preoptic area; Triazolam

Indexed keywords

MELATONIN;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG RECEPTOR BINDING; MALE; MICROINJECTION; NONHUMAN; NONREM SLEEP; PREOPTIC AREA; RAT; SLEEP;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROENCEPHALOGRAPHY; ELECTROMYOGRAPHY; HYPNOTICS AND SEDATIVES; MALE; MELATONIN; MICROINJECTIONS; PREOPTIC AREA; RATS; RATS, SPRAGUE-DAWLEY; SINGLE-BLIND METHOD; SLEEP, REM; WAKEFULNESS;

FELIS CATUS; MAMMALIA;

EID: 0037072637     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0024-3205(02)01991-4     Document Type: Article

References (14)

1. Neuropharmacology of sleep induction by benzodiazepines
2. Sleep-inducing effects of adenosine microinjections into the medial preoptic area are blocked by flumazenil
3. The sleep-inducing effect of ethanol microinjection into the medical preoptic area is blocked by flumazenil
4. Sleep induction by microinjection of pentobarbital into the medial preoptic area in rats
5. Flumazenil blocks the increase in sleep after propofol microinjection into the medical preoptic area of the rat
6. Sleep-promoting effects of melatonin: At what dose, in whom, under what conditions, and by what mechanisms?
7. Effect of transbuccal melatonin administration on sleep in elderly insomniacs
8. Efficacy of melatonin as a hypnotic agent
9. Sleep induced by the administration of melatonin (5-Methoxy-N-acetyltryptamine) to the hypothalamus in unrestrained
10. Effects of microinjections of triazolam into the ventrolateral preoptic area on sleep in the rat
11. Melatonin increases in vivo GABA accumulation in rat hypothalamus, cerebellum, cerebral cortex and pineal gland
12. Effects of chronic melatonin administration on GABA and diazepam binding in rat brain
13. Melatonin-induced depression of locomotor activity in hamsters: Time-dependency and inhibition by the central-type benzodiazepine antagonist RO 15-1788
14. Melatonin as an anxiolytic in rats: Time dependence and interaction with the central GABAergic system