A water-soluble synthetic spicamycin derivative (San-Gly) decreases mechanical allodynia in a rodent model of neuropathic pain

Neuroscience Letters

Volumn 330, Issue 1, 2002, Pages 37-40

  DiLorenzo, L ^a   Kobierski, L ^a   Moore, K A ^a   Borsook, D ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b Department of Radiology   (United States)

Author keywords

Allodynia; Neuropathic pain; Rats; SAN Gly; Spared nerve injury model; Spicamycin

Indexed keywords

SPICAMYCIN;

ALLODYNIA; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; EXCITATORY POSTSYNAPTIC POTENTIAL; MALE; MEASUREMENT; NERVE LIGATION; NEUROPATHIC PAIN; NONHUMAN; PAIN THRESHOLD; PERONEUS NERVE; PRIORITY JOURNAL; RAT; RODENT; TIBIAL NERVE;

ANIMALS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; EXCITATORY POSTSYNAPTIC POTENTIALS; MALE; PAIN MEASUREMENT; PERIPHERAL NERVOUS SYSTEM DISEASES; PERONEAL NERVE; PHYSICAL STIMULATION; PURINE NUCLEOSIDES; RATS; RATS, SPRAGUE-DAWLEY; SOLUBILITY; SPINAL CORD; TIBIAL NERVE; WATER;

EID: 0037072533     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(02)00724-3     Document Type: Article

References (11)

1. Abdi S., Vilassova N., Decosterd I., Feroz N., Borsook D. The effects of KRN5500, a spicamycin derivative, on neuropathic and nociceptive pain models in rats. Anesth. Analg. 91:2000;955-999.
2. Baba S.A., Mogami Y., Otsu T. Evaluation of gravity-dependent membrane potential shift in Paramecium. Adv. Space Res. 23:1999;2065-2073.
3. Brenner G.J., Benn S.C., Ji R.R., Woolf C.J. Pain and phosphorylation of ion channels in primary sensory and dorsal horn neurons. Soc. Neurosci. Abstr. 27:2001;14.
4. Chaplan S.R., Bach F.W., Pogrel J.W., Chung J.M., Yaksh T.L. Quantitative assessment of tactile allodynia in the rat paw. J. Neurosci. Methods. 53:1994;55-63.
5. Decosterd I., Woolf C.J. Spared nerve injury: an animal model of persistent peripheral neuropathic pain. Pain. 87:2000;149-158.
6. Hayakawa Y., Nakagawa M., Toda Y., Seto H. A new depsipeptide antibiotic, citropeptin. Agric. Biol. Chem. 54:1990;1007-1011.
7. Kobierski L.A., Abdi S., DiLorenzo L.D., Feroz N., Borsook D. A single intravenous injection of KRN5500 produces long-term decreases in multiple sensory hypersensitivities in neuropathic pain. Anesth. Analg. 2002;. submitted for publication.
8. Kohno N., Kitazawa S., Konishi M., Wakita K., Furuya Y., Kawaguti K. New treatment strategy for bone metastases from breast cancer. Breast Cancer. 6:1999;292-297.
9. Patel H.H., Hsu A., Moore J., Gross G.J. BW373U86, a delta opioid agonist, partially mediates delayed cardioprotection via a free radical mechanism that is independent of opioid receptor stimulation. J. Mol. Cell Cardiol. 33:2000;1455-1465.
10. Tal M., Bennett G. Extra-territorial pain in rats with a peripheral mononeuropathy: mechano-hyperalgesia and mechano-allodynia in the territory of an uninjured nerve. Pain. 57:1994;375-382.
11. Watkins L.R., Milligan E.D., Maier S.F. Glial activation: a driving force for pathological pain. Trends Neurosci. 24:2001;450-455.