Exploring the active site of Trypanosoma brucei phosphofructokinase by inhibition studies: Specific irreversible inhibition

Biochemistry

Volumn 41, Issue 32, 2002, Pages 10183-10193

  Claustre, Samantha ^a   Denier, Colette ^a   Lakhdar Ghazal, Faouzi ^a   Lougare, Andrée ^a   Lopez, Claudia ^b   Chevalier, Nathalie ^b   Michels, Paul A M ^b   Périé, Jacques ^a   Willson, Michèle ^a  

^a CNRS   (France)

^b DE DUVE INSTITUTE   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

AROMATIC RINGS;

ALCOHOLS; CARBON; ENZYME INHIBITION; ENZYMES; FRUCTOSE; MUTAGENESIS;

BIOCHEMISTRY;

1,2 ANHYDROMANNITOL; 6 PHOSPHOFRUCTOKINASE; CARBON; FRUCTOSE 6 PHOSPHATE; LYSINE; UNCLASSIFIED DRUG;

AFRICAN TRYPANOSOMIASIS; ARTICLE; ATOM; BINDING AFFINITY; BINDING SITE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME INACTIVATION; ENZYME INHIBITION; HYDROPHOBICITY; NONHUMAN; PARASITE; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN INTERACTION; SITE DIRECTED MUTAGENESIS; TRYPANOSOMA BRUCEI;

ADENOSINE TRIPHOSPHATE; ANIMALS; BINDING SITES; BINDING, COMPETITIVE; CIRCULAR DICHROISM; ENZYME ACTIVATION; ENZYME INHIBITORS; FRUCTOSEPHOSPHATES; KINETICS; MAGNESIUM; PHOSPHOFRUCTOKINASE-1; RECOMBINANT PROTEINS; SPECTROMETRY, FLUORESCENCE; SUBSTRATE SPECIFICITY; TRYPANOSOMA BRUCEI BRUCEI;

PROTOZOA; TRYPANOSOMA; TRYPANOSOMA BRUCEI;

EID: 0037072283     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi020082z     Document Type: Article

References (38)