Effect of supplementation with folic-acid on relation between plasma homocysteine, folate, and vitamin B12 [3]

Lancet

Volumn 360, Issue 9327, 2002, Pages 171-172

  Ashfield Watt, P A L ^a   Moat, S J ^b   Newcombe, R G ^b   McDowell, I F W ^b   McPartlin, Joe ^c   McNulty, Helene ^e   Quinlivan, Eoin ^e   Ward, Mary ^e   Scott, John ^e   McCaddon, Andrew ^d   Hudson, Peter ^e   Ellis, Dick ^e   Hill, Diane ^e   Lloyd, Alwyn ^e  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b CARDIFF UNIVERSITY   (United Kingdom)

^c TRINITY COLLEGE DUBLIN   (Ireland)

^d Surgery   (United Kingdom)

^e NONE

Author keywords

[No Author keywords available]

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); CYANOCOBALAMIN; FOLIC ACID; HAPTOCORRIN; HOMOCYSTEINE;

CHEMOLUMINESCENCE; CORRELATION ANALYSIS; DATA ANALYSIS; DEMENTIA; DIET SUPPLEMENTATION; DOSE RESPONSE; ENZYME ACTIVITY; FOLIC ACID BLOOD LEVEL; GENETIC POLYMORPHISM; GENOTYPE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; LETTER; LINEAR REGRESSION ANALYSIS; PRIORITY JOURNAL; VITAMIN BLOOD LEVEL;

EID: 0037072093     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0140-6736(02)09393-5     Document Type: Letter

References (4)

1. Importance of both folic acid and vitamin B12 in reduction of risk of vascular disease
2. Optimisation of dietary folate or low-dose folic acid supplements lower homocysteine but do not enhance endothelial function in healthy adults irrespective of methylenetetrahydrofolate reductase (C677T) genotype
3. Methylenetetrahydrofolate reductase (C677T) genotype modulates blood homocysteine responses to a folate rich diet or low dose folic acid supplement: A randomised controlled trial
4. The common 'thermolabile' variant of methylenetetrahydrofolate reductase is a major determinant of mild hyperhomocysteinaemia