N-acetylcysteine for paracetamol poisoning: Effect on prothrombin

Lancet

Volumn 360, Issue 9340, 2002, Pages 1115-

  Pol, Stanislas ^a   Lebray, Pascal ^a  

^a HÔPITAL NECKER ENFANTS MALADES   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; BLOOD CLOTTING FACTOR 5; PARACETAMOL; PROTHROMBIN;

DRUG EFFECT; DRUG MECHANISM; HEPATITIS; HUMAN; LIVER FAILURE; LIVER TOXICITY; LIVER TRANSPLANTATION; MORTALITY; NOTE; PRIORITY JOURNAL; PROGNOSIS; PROTHROMBIN TIME; SURVIVAL;

EID: 0037068962     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(02)11238-4     Document Type: Note

References (11)

1. Vale J.A., Proudfoot A.T. Paracetamol (acetaminophen) poisoning. Lancet. 346:1995;547-552.
2. Devlin J., Wendon J., Heaton N., Tan K.-C., Williams R. Pretransplant clinical status and outcome of emergency transplantation for acute liver failure. Hepatology. 21:1995;1018-11025.
3. Harrison P.M., Keays R., Bray G.P., et al. Improved outcome in paracetamol-induced fulminant failure following late administration of acetylcysteine. Lancet. 335:1990;1572-1573.
4. Prescott L.F., Illingworth R.N., Crichtley J.A.J.H., Stewart M.J., Adam R.D., Proudfoot A.T. Intravenous N-acetylcysteine: the treatment of choice for paracetamol poisoning. BMJ. 2:1979;1097-1100.
5. Makin A.L., Wendon J., Williams R. A 7-year experience of severe acetaminophen-induced hepatoxicity. Gastroenterology. 109:1995;1907-1916.
6. Bernuau J., Goudeau A., Poynard T., et al. Multivariate analysis of prognostic factors in fulminant hepatitis B. Hepatology. 6:1986;648-651.
7. O'Grady J.G., Alexander G.J.M., Hayllar K.M., Williams R. Early indicators of prognosis in fulminant hepatic failure. Gastroenterology. 97:1989;439-445.
8. O'Grady J.G., Hambley H., Williams R. Prothrombin time in fulminant failure. Gastroenterology. 100:1991;1480-1481.
9. Izumi S., Langley P.G., Wendon J., et al. Coagulation factor V levels as a prognostic indicator in fulminant hepatic failure. Gastroenterology. 23:1996;1507-1511.
10. Jepsen S., Hansen A.B. The influence of N-acetylcysteine on the measurement of prothrombin time and activated thromboplastin time in healthy subjects. Scand J Clin Lab Invest. 54:1994;543-547.
11. Jepsen S., Herlevsen P., Knudsen P., Bud M.I., Klausen N.O. Antioxidant treatment with N-acetylcysteine during adult respiratory distress syndrome: a prospective, randomized, placebo-controlled study. Crit Care Med. 20:1992;918-923.