A comparison of the anti-nociceptive effects of voltage-activated Na+ channel blockers in the formalin test

European Journal of Pharmacology

Volumn 445, Issue 3, 2002, Pages 231-238

  Blackburn Munro, Gordon ^a   Ibsen, Nete ^a   Erichsen, Helle K ^a  

^a NEUROSEARCH A S   (Denmark)

Author keywords

Formalin test; Hyperalgesia; Inflammation; Ion channels; Neuropathic pain

Indexed keywords

ANTIARRHYTHMIC AGENT; ANTICONVULSIVE AGENT; CARBAMAZEPINE; FORMALDEHYDE; LAMOTRIGINE; LUBELUZOLE; MEXILETINE; PHENYTOIN; RILUZOLE; SODIUM CHANNEL BLOCKING AGENT; ANALGESIC AGENT; SODIUM CHANNEL;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; MALE; MOTOR DYSFUNCTION; NEUROPSYCHOLOGICAL TEST; NONHUMAN; PRIORITY JOURNAL; RAT; THERMAL STIMULATION; ANIMAL; COMPARATIVE STUDY; METHODOLOGY; PAIN ASSESSMENT; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ANALGESICS; ANIMAL; COMPARATIVE STUDY; DOSE-RESPONSE RELATIONSHIP, DRUG; MALE; PAIN MEASUREMENT; RATS; RATS, SPRAGUE-DAWLEY; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS; SUPPORT, NON-U.S. GOV'T; ANIMALS;

EID: 0037066906     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(02)01765-X     Document Type: Article

References (38)

1. The formalin test: Scoring properties of the first and second phases of the pain response in rats
2. Lack of analgesic effect of opioids on neuropathic and idiopathic forms of pain
3. +-channel function as an in vitro model of the ischemic penumbra: Action of lubeluzole and other neuroprotective drugs
4. Anticonvulsants and antiarrthymics in the treatment of neuropathic pain syndromes
5. + channels in pain pathways
6. + channel blockers on somatosensory processing by rat dorsal horn neurones
7. + currents in rat sensory neurones
8. Lamotrigine control of central pain
9. + channels: Local anesthetics, antiarrhythmics and anticonvulsants
10. Efficacy of spinal NMDA receptor antagonism in formalin hyperalgesia and nerve injury evoked allodynia in the rat
11. A novel spinal action of mexiletine in spinal somatosensory neurone transmission of nerve injured rats
12. The contribution of excitatory amino acids to central sensitization and persistent nociception after formalin-induced tissue injury
13. Lubeluzole protects hippocampal neurons from excitotoxicity in vitro and reduces brain damage caused by ischemia
14. Subcutaneous formalin induced activity of dorsal horn neurones in the rat: Differential response to an intrathecal opiate administered pre or post formalin
15. Ions in the fire: Recent ion-channel research and approaches to pain therapy
16. Pharmacological characterisation of the spared nerve injury model of neuropathic pain
17. + current in nociceptors
18. A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia
19. The formalin test in mice: Dissociation between inflammatory and non-inflammatory pain
20. The effect of novel anti-epileptic drugs in rat experimental models of acute and chronic pain
21. The effects of mexiletine, desipramine and fluoxetine in rat models involving central sensitization
22. Molecular mechanisms of nociception
23. + currents: Quantitative distinction from phenytoin and possible therapeutic implications
24. Analgesic activity of a novel use-dependent sodium channel blocker, crobenetine, in mono-arthritc rats
25. Studies on the mechanism of action of the novel anticonvulsant lamotrigine (Lamictal) using primary neuroglial cultures from rat cortex
26. 2 using microdialysis in conscious rats
27. Quantitative systematic review of topically applied non-steroidal anti-inflammatory drugs
28. 2 and in the chronic hyperalgesia in rats with streptozotocin-induced diabetes
29. Sodium channels as molecular targets for antiepileptic drugs
30. Phenytoin and carbamazepine: Differential inhibition of sodium currents in small cells from adult dorsal root ganglia
31. Kainate GluR5 receptor subtype mediates the nocieptive response to formalin in the rat
32. Sodium channel blocking agents: Their use in neuropathic pain conditions
33. Two sodium channels contribute to the TTX-R sodium current in primary sensory neurons
34. The molecular pathophysiology of pain: Abnormal expression of sodium channel genes and its contributions to hyperexcitability of primary sensory neurons mRNA is expressed in embryonic but not adult spinal sensory neurons
35. Neuronal plasticity: Increasing the gain in pain
36. + currents in rat sensory neurons by lamotrigine
37. Differential effects of NMDA and group I mGluR antagonists on both nociception and spinal cord protein kinase C translocation in the formalin test and a model of neuropathic pain in rats
38. Ethical guidelines for investigations of experimental pain in conscious animals