Characterization of the 5′-flanking region of the human PTK6 gene

Biochimica et Biophysica Acta - Gene Structure and Expression

Volumn 1574, Issue 3, 2002, Pages 365-369

  Kang, Kyung Nam ^a   Kim, Mirang ^a   Pae, Kwang Min ^a   Lee, Seung Taek ^a  

^a Yonsei University   (South Korea)

Author keywords

Promoter; Protein tyrosine kinase 6; Transcription factor; Tyrosine kinase

Indexed keywords

CELL EXTRACT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LUCIFERASE; MESSENGER RNA; MONOCLONAL ANTIBODY; OLIGONUCLEOTIDE; PREGNANCY SPECIFIC BETA1 GLYCOPROTEIN; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE 6; UNCLASSIFIED DRUG; COMPLEMENTARY DNA; PTK6 PROTEIN, HUMAN; TUMOR PROTEIN;

ANALYTIC METHOD; ARTICLE; CARCINOMA CELL; CELL NUCLEUS; CODON; COMPARATIVE STUDY; CONTROLLED STUDY; DNA FLANKING REGION; ENZYME ACTIVITY; ENZYME ANALYSIS; GEL MOBILITY SHIFT ASSAY; GENE; GENE CONSTRUCT; GENE DELETION; GENE EXPRESSION; GENE FUNCTION; GENE FUSION; GENE LOCATION; GENE SEQUENCE; GENETIC ANALYSIS; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; REPORTER GENE; TRANSCRIPTION REGULATION; TRANSLATION INITIATION; CELL CULTURE; CHEMISTRY; GENETICS; PLASMID; TRANSCRIPTION INITIATION SITE;

DNA, COMPLEMENTARY; HUMANS; LUCIFERASES; NEOPLASM PROTEINS; PLASMIDS; POLYMERASE CHAIN REACTION; PROMOTER REGIONS (GENETICS); PROTEIN-TYROSINE KINASES; TRANSCRIPTION INITIATION SITE; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0037066805     PISSN: 01674781     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-4781(02)00234-8     Document Type: Article

References (33)

1. A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes
2. Cloning and characterisation of cDNAs encoding a novel non-receptor tyrosine kinase, brk, expressed in human breast tumours
3. A novel intracellular epithelial cell tyrosine kinase is expressed in the skin and gastrointestinal tract
4. Exon-intron structure of the human PTK6 gene demonstrates that PTK6 constitutes a distinct family of non-receptor tyrosine kinase
5. BRK/Sik expression in the gastrointestinal tract and in colon tumors
6. BRK tyrosine kinase expression in a high proportion of human breast carcinomas
7. The human PTK6 interacts with a 23-kDa tyrosine-phosphorylated protein and is localized in cytoplasm in breast carcinoma T-47D cells
8. Loss of expression of receptor tyrosine kinase family genes PTK7 and SEK in metastatic melanoma
9. Comparative tyrosine-kinase profiles in colorectal cancers: Enhanced arg expression in carcinoma as compared with adenoma and normal mucosa
10. Characterisation and chromosome mapping of the human non receptor tyrosine kinase gene, brk
11. A role for the epithelial-cell-specific tyrosine kinase Sik during keratinocyte differentiation
12. Transcription initiation from TATA-less promoters within eukaryotic protein-coding genes
13. Selection of optimal kappa B/Rel DNA-binding motifs: Interaction of both subunits of NF-kappa B with DNA is required for transcriptional activation
14. Differential regulation of constitutive and retinoic acid-induced galectin-1 gene transcription in murine embryonal carcinoma and myoblastic cells
15. Nuclear factor-kappa B, cancer, and apoptosis
16. Brk, a breast tumor-derived non-receptor protein-tyrosine kinase, sensitizes mammary epithelial cells to epidermal growth factor
17. Expression of the BRK tyrosine kinase in mammary epithelial cells enhances the coupling of EGF signalling to PI 3-kinase and Akt, via erbB3 phosphorylation
18. The Sp-family of transcription factors
19. An interaction between the DNA-binding domains of RelA(p65) and Sp1 mediates human immunodeficiency virus gene activation
20. Different members of the Sp1 multigene family exert opposite transcriptional regulation of the long terminal repeat of HIV-1
21. A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells
22. Positive and negative elements regulate human interleukin 3 expression
23. Cloning by recognition site screening of two novel GT box binding proteins: A family of Sp1 related genes
24. Transcription of the human c-Src promoter is dependent on Sp1, a novel pyrimidine binding factor SPy, and can be inhibited by triplex-forming oligonucleotides
25. The transcription factor Sp1 regulates the myeloid-specific expression of the human hematopoietic cell kinase (HCK) gene through binding to two adjacent GC boxes within the HCK promoter-proximal region
26. The myeloid-cell-specific c-fes promoter is regulated by Sp1, PU.1, and a novel transcription factor
27. The human EGF receptor gene: Structure of the 110 kb locus and identification of sequences regulating its transcription
28. Regulation of insulin-like growth factor I receptor gene expression by Sp1: Physical and functional interactions of Sp1 at GC boxes and at a CT element
29. Transcription factors Sp1 and Sp3 alter vascular endothelial growth factor receptor expression through a novel recognition sequence
30. Transcriptional activation of the hepatocyte growth factor receptor (c-met) gene by its ligand (hepatocyte growth factor) is mediated through AP-1
31. A cluster of four Sp1 binding sites required for efficient expression of the human insulin receptor gene
32. Two distal Sp1-binding cis-elements regulate fibroblast growth factor receptor 1 (FGFR1) gene expression in myoblasts