In vivo metabolism and clearance of substance P and co-expressed tachykinins in rat striatum

Neuroscience

Volumn 110, Issue 2, 2002, Pages 277-286

  Michael Titus, A T ^a   Fernandes, K ^a   Setty, H ^a   Whelpton, R ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Kinetics; Neurokinin A; Neuropeptide ; Neuropeptide K; Peptidase inhibitors; Peptides

Indexed keywords

AMINOPEPTIDASE; BESTATIN; CAPTOPRIL; DIPEPTIDYL CARBOXYPEPTIDASE; NEUROKININ A; NEUROPEPTIDE GAMMA; NEUROPEPTIDE K; PROTEINASE; SUBSTANCE P; TACHYKININ; THIORPHAN; TRITIUM;

AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CAPILLARY ELECTROPHORESIS; CHEMICAL LABELING; CLEARANCE; CONTROLLED STUDY; EXTRACELLULAR SPACE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VIVO STUDY; MALE; METABOLITE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN METABOLISM; RAT; SIGNAL TRANSDUCTION;

ANIMALS; EXTRACELLULAR SPACE; LEUCINE; MALE; NEOSTRIATUM; NEUROKININ A; NEURONS; NEUROPEPTIDES; PEPTIDE FRAGMENTS; PROLINE; PROTEASE INHIBITORS; PROTEIN STRUCTURE, TERTIARY; RATS; RATS, WISTAR; SUBCELLULAR FRACTIONS; SUBSTANCE P; TACHYKININS; TRITIUM;

EID: 0037066070     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(01)00530-9     Document Type: Article

References (64)

1. Central effects of neuropeptide K on water and food intake in the rat
2. In-vivo metabolism of substance-P in rat striatum utilizing microdialysis liquid-chromatography micro-electrospray mass-spectrometry
3. Preprotachykinin gene expression in the human basal ganglia: Characterization of mRNAs and pre-mRNAs produced by alternate RNA splicing
4. Substance P and neurokinin A regulate by different mechanisms dopamine release from dendrites and nerve terminals of the nigrostriatal dopaminergic neurons
5. Cleavage of substance P to an N-terminal tetrapeptide and a C-terminal heptapeptide by a post-proline cleaving enzyme from bovine brain
6. Localization of substance P-like immunoreactivity in neurons and nerve terminals in the neostriatum of the rat: A correlated light and electron microscopic study
7. Role of a serine endopeptidase in the hydrolysis of exogenous cholecystokinin by brain slices
8. Structure, expression, and some regulatory mechanisms of the rat preprotachykinin gene encoding substance P, neurokinin A, neuropeptide K, and neuropeptide gamma
9. Carboxyl-terminal tripeptidyl hydrolysis of substance P by purified rabbit lung angiotensin-converting enzyme and the potentiation of substance P activity in vivo by captopril and MK-422
10. Specificity of neurotensin metabolism by regional rat brain slices
11. Conversion of neuropeptide K to neurokinin A and vesicular colocalization of neurokinin A and substance P in neurons of the guinea pig small intestine
12. Modulation of the hypothalamo-pituitary-gonadal axis and the pineal gland by neurokinin A, neuropeptide K and neuropeptide gamma
13. In vivo and in vitro effects of neuropeptide K and neuropeptide gamma on the release of growth hormone
14. Probing the brain and spinal cord with neuropeptides in pathways related to pain and other functions
15. Modulation of memory retention by neuropeptide K
16. Mechanistic implications of the inhibition of peptidases by amino aldehydes and bestatin
17. Substance P release from rat nucleus accumbens and striatum: An in vivo study using antibody microprobes
18. In vivo detection of immunoreactive neurokinin A release within rat substantia nigra and its dependency on a dopaminergic input
19. The effects of the aminopeptidase inhibitors amastatin and bestatin on angiotensin-evoked neuronal activity in rat brain
20. The substance P(1-7) fragment is a potent modulator of substance P actions in the brain
21. Liver dipeptidyl aminopeptidase IV hydrolyzes substance P
22. Substance K excites dopaminergic and non-dopaminergic neurons in rat substantia nigra
23. Neuropeptide-gamma: A peptide isolated from rabbit intestine that is derived from gamma-preprotachykinin
24. Neuropeptide K stimulates corticosterone release in the rat
25. Diverse effects of tachykinins on luteinizing hormone release in male rats: Mechanism of action
26. Substance P-(1-7) and substance P-(5-11) locally modulate dopamine release in rat striatum
27. Evidence for modulatory effects of substance P fragments (1-4) and (8-11) on endogenous dopamine outflow in rat striatal slices
28. Evaluation of capillary electrophoresis with post-column derivatization and laser-induced fluorescence detection for the determination of substance P and its metabolites
29. Purification and characterisation of a membrane-bound substance-P-degrading enzyme from human brain
30. Relationship between neurokinin-1 receptor and substance P in the striatum: Light and electron microscopic immunohistochemical study in the rat
31. Tissue levels and in vivo release of tachykinins and GABA in striatum and substantia nigra of rat brain after unilateral striatal dopamine denervation
32. Synaptic relationship between substance P and the substance P receptor: Light and electron microscopic characterization of the mismatch between neuropeptides and their receptors
33. Substance P and [Leu]enkephalin are hydrolyzed by an enzyme in pig caudate synaptic membranes that is identical with the endopeptidase of kidney microvilli
34. The metabolism of neuropeptides. The hydrolysis of peptides, including enkephalins, tachykinins and their analogues, by endopeptidase-24.11
35. Is substance P released from slices of the rat spinal cord inactivated by peptidase(s) distinct from both 'enkephalinase' and 'angiotensin-converting enzyme'?
36. Enkephalinase is involved in the degradation of endogenous substance P released from slices of rat substantia nigra
37. Proteolytic inactivation of substance P in the epithelial layer of the intestine
38. Diffusion from an injected volume of a substance in brain tissue with arbitrary volume fraction and tortuosity
39. Processing of prodynorphin-derived peptides in striatal extracts. Identification by electrospray ionization mass spectrometry linked to size-exclusion chromatography
40. Metalloendopeptidase (EC 3.4.24.11) but not angiotensin converting enzyme is involved in the inactivation of substance P by synaptic membranes of the rat substantia nigra
41. Bestatin inhibition of human tissue carnosinase, a non-specific cytosolic dipeptidase
42. Cardiovascular and sympathoadrenal responses to intrathecal injection of neuropeptide K in the conscious rat
43. Differential sensitivity of presumed dopaminergic and non-dopaminergic neurones in rat substantia nigra to electrophoretically applied substance P
44. Neuropeptide gamma: A mammalian tachykinin endowed with potent antidipsogenic action in rats
45. Cardiovascular responses to intrathecal neuropeptide gamma in conscious rats: Receptor characterization and mechanism of action
46. Intranigral substance P stimulation of striatal dopamine release is inhibited by spantide II: A new tachykinin antagonist without apparent neurotoxicity
47. Inhibition of aminopeptidases by amastatin and bestatin derivatives. Effect of inhibitor structure on slow-binding processes
48. Protection by serine peptidase inhibitors of endogenous cholecystokinin released from brain slices
49. Phosphoramidon potentiates mammalian tachykinin-induced biting, licking and scratching behaviour in mice
50. Bronchoconstrictor activities of NP gamma and NPK in anaesthetized guinea-pigs: Effect on NEP inhibition
51. Hydrolysis of substance P and neurotensin by converting enzyme and neutral endopeptidase
52. In vivo conversion of vasopressin after microinjection into limbic brain areas of rats
53. 3H]captopril: Localization to a striatonigral pathway
54. Neuropeptide K: Isolation, structure and biological activities of a novel brain tachykinin
55. Differential contribution of substance P and neurokinin A to spinal cord neurokinin-1 receptor signaling in the rat
56. Distribution of neuropeptide K-immunoreactivity in the rat central nervous system
57. Autoradiographic comparison of the distribution of the neutral endopeptidase 'enkephalinase' and of mu and delta opioid receptors in rat brain
58. Neuropeptide metabolism on intact, regional brain slices: Effect of dopaminergic agents on substance P, cholecystokinin and Met-enkephalin degradation
59. Identification of substance P metabolites using a combination of reversed-phase high-performance liquid chromatography and capillary electrophoresis
60. The slow, tight binding of bestatin and amastatin to aminopeptidases
61. A new feature of angiotensin-converting enzyme in the brain: Hydrolysis of substance P
62. Identification of metabolic pathways of brain angiotensin II and III using specific aminopeptidase ihibitors: Predominant role of angiotensin III in the control of vasopressin release
63. Volume transmission in the CNS and its relevance for neuropsychopharmacology