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. For a recent paper in this series, see: Bradshaw B., Dinsmore A., Ajana W., Collison D., Garner C.D., Joule J.A. J. Chem. Soc., Perkin Trans. 1. 2001;3239-3244.
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Sequin-Frey, M.4
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0345392985
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0035813244
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. for a recent review on microwave assisted organic synthesis, see: Lidstrom P., Tierney J., Wathey B., Westman J. Tetrahedron. 57:2001;9225-9283.
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85069417273
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Typical experimental procedure: A mixture of 2,5,6-triaminopyrimidin-4(3H)-one hydrochloride 3 (2.0 g) and methylglyoxal (1.5 g, 40% in water) was placed in a microwave oven (BPL 800G, indicates the commercial name of the microwave oven) and subjected to irradiation at 150 W for an optimised time (62 s). Water was then added and the resulting slurry was centrifuged. The solid separated was filtered through a sintered funnel, washed well with water and then with ethanol, and dried in vacuum. The bright yellow solid (1.2 g, 70%, mp>350°C) after pivaloylation with pivalic anhydride followed by purification gave a cream coloured solid 1b (1.4 g, 78%, mp 230-232°C). Compounds 1d, 1f and 2c were obtained by condensation followed by direct acetylation of 1c, 1e and 2b, respectively.
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Typical experimental procedure: A mixture of 2,5,6-triaminopyrimidin-4(3H)-one hydrochloride 3 (2.0 g) and methylglyoxal (1.5 g, 40% in water) was placed in a microwave oven (BPL 800G, indicates the commercial name of the microwave oven) and subjected to irradiation at 150 W for an optimised time (62 s). Water was then added and the resulting slurry was centrifuged. The solid separated was filtered through a sintered funnel, washed well with water and then with ethanol, and dried in vacuum. The bright yellow solid (1.2 g, 70%, mp>350°C) after pivaloylation with pivalic anhydride followed by purification gave a cream coloured solid 1b (1.4 g, 78%, mp 230-232°C). Compounds 1d, 1f and 2c were obtained by condensation followed by direct acetylation of 1c, 1e and 2b, respectively.
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23
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85069416930
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Sato, H.; Nakajima, M.; Tanaka, H. J. Chem. Soc. Jpn. 1951, 72, 868-870. Chem. Abstr. 1953, 5946-5947.
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Sato, H.1
Nakajima, M.2
Tanaka, H.3
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24
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0003993823
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Sato, H.; Nakajima, M.; Tanaka, H. J. Chem. Soc. Jpn. 1951, 72, 868-870. Chem. Abstr. 1953, 5946-5947.
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(1953)
Chem. Abstr.
, pp. 5946-5947
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85069413723
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note
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+): 418 (100%).
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