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Volumn 43, Issue 46, 2002, Pages 8371-8373

The first microwave-assisted regiospecific synthesis of 6-substituted pterins

Author keywords

6 substituted pterins; Isay condensation; Microwave; Molybdenum cofactor; Quinoxalines

Indexed keywords

BENZENE; CARBOHYDRATE DERIVATIVE; PTERIN DERIVATIVE; PYRIMIDINE; QUINOXALINE DERIVATIVE;

EID: 0037064524     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(02)02007-5     Document Type: Article
Times cited : (52)

References (32)
  • 8
    • 0000273676 scopus 로고    scopus 로고
    • Hille R. Chem. Rev. 96:1996;2757-2816.
    • (1996) Chem. Rev. , vol.96 , pp. 2757-2816
    • Hille, R.1
  • 21
    • 85069417273 scopus 로고    scopus 로고
    • Typical experimental procedure: A mixture of 2,5,6-triaminopyrimidin-4(3H)-one hydrochloride 3 (2.0 g) and methylglyoxal (1.5 g, 40% in water) was placed in a microwave oven (BPL 800G, indicates the commercial name of the microwave oven) and subjected to irradiation at 150 W for an optimised time (62 s). Water was then added and the resulting slurry was centrifuged. The solid separated was filtered through a sintered funnel, washed well with water and then with ethanol, and dried in vacuum. The bright yellow solid (1.2 g, 70%, mp>350°C) after pivaloylation with pivalic anhydride followed by purification gave a cream coloured solid 1b (1.4 g, 78%, mp 230-232°C). Compounds 1d, 1f and 2c were obtained by condensation followed by direct acetylation of 1c, 1e and 2b, respectively.
    • Typical experimental procedure: A mixture of 2,5,6-triaminopyrimidin-4(3H)-one hydrochloride 3 (2.0 g) and methylglyoxal (1.5 g, 40% in water) was placed in a microwave oven (BPL 800G, indicates the commercial name of the microwave oven) and subjected to irradiation at 150 W for an optimised time (62 s). Water was then added and the resulting slurry was centrifuged. The solid separated was filtered through a sintered funnel, washed well with water and then with ethanol, and dried in vacuum. The bright yellow solid (1.2 g, 70%, mp>350°C) after pivaloylation with pivalic anhydride followed by purification gave a cream coloured solid 1b (1.4 g, 78%, mp 230-232°C). Compounds 1d, 1f and 2c were obtained by condensation followed by direct acetylation of 1c, 1e and 2b, respectively.
  • 24
    • 0003993823 scopus 로고
    • Sato, H.; Nakajima, M.; Tanaka, H. J. Chem. Soc. Jpn. 1951, 72, 868-870. Chem. Abstr. 1953, 5946-5947.
    • (1953) Chem. Abstr. , pp. 5946-5947
  • 29
    • 85069413723 scopus 로고    scopus 로고
    • note
    • +): 418 (100%).


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.