A comparative molecular field analysis (COMFA) of the structural determinants of heat-stable enterotoxins mediating activation of guanylyl cyclase C

Journal of Medicinal Chemistry

Volumn 45, Issue 8, 2002, Pages 1731-1734

  Wolfe, Henry R ^a,b   Waldman, Scott A ^b  

^a Targeted Diagnostics and Therapeutics Inc   (United States)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENTEROTOXIN; GUANYLATE CYCLASE; GUANYLATE CYCLASE C; GUANYLIN; MEMBRANE RECEPTOR; UNCLASSIFIED DRUG; UROGUANYLIN;

APICAL MEMBRANE; ARTICLE; COMPUTER MODEL; DISULFIDE BOND; DRUG RECEPTOR BINDING; ELECTROLYTE TRANSPORT; ENZYME ACTIVATION; LIGAND BINDING; MOLECULAR MODEL; PROTEIN DOMAIN; SECRETION;

AMINO ACID SEQUENCE; ENTEROTOXINS; GUANYLATE CYCLASE; HEAT; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; RECEPTORS, PEPTIDE;

EID: 0037061640     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm010208a     Document Type: Article

References (50)

1. Epidemiology of enterotoxigenic Eschericia coli diarrhea in a pediatric cohort in a periurban area of lower Egypt
2. Escherichia coli heat-stable enterotoxin in feces and intestines of calves with diarrhea
3. Amino acid sequence of heat-stable enterotoxin produced by Escherichia coli pathogenic for man
4. Mode of disulfide bond formation of a heat-stable enterotoxin (STh) produced by a human strain of enterotoxigenic. Eschericia coli
5. Importance of disulfide bridges in the structure and activity of Eschericia coli enterotoxin STIb
6. A heat-stable enterotoxin of Vibrio cholera non-01: Chemical synthesis, and biological and physicochemical properties
7. Heat stable enterotoxigenic Eschericia coli (Strain SK-1). Structure-activity relationship
8. Enteroaggregative Eschericia coli heat stable enterotoxin I represents another subfamily of E. coli heat-stable toxin
9. Guanylin: An endogenous activator of intestinal guanylate cyclase
10. Uroguanylin: Structure and activity of a second endogenous peptide that stimulates intestinal guanylate cyclase
11. Synthesis, solution structure, binding activity, and cGMP activation of human guanylin and its disulfide isomer
12. Binding of Eschericia coli heat-stable enterotoxin in rat intestinal cells and brush border membranes
13. The Escherichia coli heat-stable enterotoxin is a long-lived superagonist of guanylin
14. Suckling mouse model for detection of Eschericia coli heat stable enterotoxin: Characteristics of the model
15. Mice lacking the guanylyl cyclase C receptor are resistant to STa-induced intestinal secretion
16. Min/+ mouse and induces apoptosis in human colon adenocarcinoma cells via cyclic GMP
17. Guanylyl cyclase C agonists regulate progression through the cell cycle of human colon cascinoma cells
18. Cyclic GMP-dependent protein kinase activation and induction by exisulind and CP461 in colon tumor cells
19. Eschericia coli heat stable enterotoxin receptors: A novel marker for colorectal tumors
20. Guanylyl cyclase C is a selective marker for metastatic colorectal tumors in human extraintestinal tissues
21. Use of guanylyl cyclase C for detecting micrometastases in lymph nodes of patients with colon cancer
22. Guanylyl cyclase C messenger RNA is a biomarker for recurrent stage II colorectal cancer
23. Development and characterization of a receptor-avid In-111-labeled peptide for site-specific targeting of colon cancer
24. Synthesis and antigenic activity of E. coli ST and its analogues
25. Chemical synthesis of a highly potent heat stable analogue of an enterotoxin produced by a human strain of enterotoxigenic Eschericia coli
26. Design of a photoreactive analogue of the Escherichia coli heat-stable enterotoxin STIb: Use in identifying its receptor on rat brush border membranes
27. The lysine-1 analogue of guanylin induces intestinal secretion and natriuresis in the isolated perfused kidney
28. Synthesis and biological properties of carba-analogues of heat-stable enterotoxin (ST) produced by enterotoxigenic Escherichia coli
29. Chemical synthesis of an octadecapeptide with the biological and immunological properties of human heat-stable Escherichia coli enterotoxin
30. A long-acting heat-stable enterotoxin analogue of enterotoxigenic Escherichia coli with a single D-amino acid
31. Substitutions of cysteine residues of Escherichia coli heat-stable enterotoxin by oligonucleotide-directed mutagenesis
32. Reduction of enterotoxic activity of Escherichia coli heat-stable enterotoxin by substitution for an asparagine residue
33. Enterotoxicity and immunological properties of two mutant forms of Escherichia coli STIp with lysine or arginine substituted for the asparagine residue at position 11
34. Molecular structure of the toxin domain of heat-stable enterotoxin produced by a pathogenic strain of Escherichia coli. A putative binding site for a binding protein on rat intestinal epithelial cell membranes
35. Essential structure for full enterotoxigenic activity of heat-stable enterotoxin produced by enterotoxigenic Escherichia coli
36. Structural characteristics for biological activity of heat-stable enterotoxin produced by enterotoxigenic Escherichia coli: X-ray crystallography of weakly toxic and nontoxic analogues
37. Synthesis of a heat-stable enterotoxin produced a human strain of enterotoxigenic Eschericia coli
38. Structure activity relationship of Eschericia coli heat stable enterotoxin: Role of Ala residue at position 14 in toxin receptor interactions
39. Conformational Molecular Field Analysis (COMFA): Effect of shape on binding of steroids to carrier proteins
40. Type II' to type I-turn swap changes specificity for integrins
41. Crossvalidation, bootstrapping and partial least squares compared with multiple regression in conventional QSAR studies
42. Restart procedures for the CG method
43. Numerical recipes in C
44. The Tripos force field
45. Primary structure of heat-stable enterotoxin produced by Yersinia enterocolitica
46. Characterization of a highly toxic, large molecular size heat stable enterotoxin produced by a clinica isolate of Yersinia enterocolitica
47. Influence of a glycine or praline substitution on the fuctional properties of a 14-amino acid analogue of Escherichia coli heat-stable enterotoxin