Mathematical representation of apparent dissociation constants in aqueous-organic solvent mixtures

International Journal of Pharmaceutics

Volumn 246, Issue 1-2, 2002, Pages 135-142

  Jouyban, Abolghasem ^a   Chan, Hak Kim ^b   Clark, Brian J ^c   Acree Jr , William E ^d  

^a TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b UNIVERSITY OF SYDNEY   (Australia)

^c UNIVERSITY OF BRADFORD   (United Kingdom)

^d UNIVERSITY OF NORTH TEXAS   (United States)

Author keywords

Acid dissociation constant; Cosolvency; Hydroorganic mixtures

Indexed keywords

1,4 PIPERAZINEBIS(ETHANESULFONIC ACID); 2 [BIS(2 HYDROXYETHYL)AMINO]ETHANESULFONIC ACID; 2 MORPHOLINOETHANESULFONIC ACID; 2 PROPANOL; 4 (2 HYDROXYETHYL) 1 PIPERAZINEETHANESULFONIC ACID; 4 AMINOBENZOIC ACID; ACETIC ACID; ALCOHOL; BENZOIC ACID; BORIC ACID; CARPROFEN; CITRIC ACID; DICLOFENAC; DIMETHYL SULFOXIDE; FENBUFEN; FLURBIPROFEN; GLYCEROL; IBUPROFEN; KETOPROFEN; MACROGOL 400; METHANOL; N (2 ACETAMIDO) 2 AMINOETHANESULFONIC ACID; N [TRIS(HYDROXYMETHYL)METHYL]GLYCINE; NAPROXEN; ORGANIC SOLVENT; PHTHALIC ACID; PROPYLENE GLYCOL; TETRAHYDROFURAN; TRICINE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

AQUEOUS SOLUTION; ARTICLE; CALCULATION; CHEMICAL COMPOSITION; CONCENTRATION RESPONSE; CORRELATION ANALYSIS; DRUG SOLUBILITY; EVALUATION; MATHEMATICAL MODEL; PREDICTION; PRIORITY JOURNAL; RACEMIC MIXTURE;

2-PROPANOL; ACIDS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CHEMISTRY, PHYSICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DATA INTERPRETATION, STATISTICAL; ELECTROPHORESIS, CAPILLARY; MODELS, CHEMICAL; PHARMACEUTICAL SOLUTIONS; PREDICTIVE VALUE OF TESTS; SOLVENTS; WATER;

EID: 0037057332     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(02)00355-1     Document Type: Article

References (9)

1. Acree W.E. Mathematical representation of thermodynamic properties. Part II. Derivation of the combined nearly ideal binary solvent (NIBS)/Redlich-Kister mathematical representation from a two-body and three-body interactional mixing model. Thermochim. Acta. 198:1992;71-79.
2. Azab H.A. Potentiometric determination of the second-stage dissociation constants of some hydrogen ion buffers for biological research in various water+organic solvent mixtures. J. Chem. Eng. Data. 38:1993;453-457.
3. Azab H.A., Hassan A., Khafagy Z.A. Potentiometric determination of the second-stage dissociation constant of N,N-bis(2-hydroxyethyl)-2-aminoethanesulfonic acid in various water+organic solvent mixtures. J. Chem. Eng. Data. 38:1993;231-233.
4. Barbosa J., Berges R., Toro I., Sanz-Nebot V. Dissociation constants and preferential solvation of fluoroquinolones in hydroorganic mixtures used in LC. Int. J. Pharm. 149:1997;213-225.
5. Barbosa J., Barron D., Beltran J.L., Buti S. On the role of solvent in acid-base equilibria of diuretics in acetonitrile-water mixed solvents. Talanta. 45:1998;817-827.
6. a values of quinolones in hydroorganic mixtures. J. Pharm. Biomed. Anal. 24:2001;1087-1098.
7. Barron D., Buti S., Ruiz M., Barbosa J. Evaluation of acidity constants and preferential solvation in tetrahydrofuran-water mixtures. Polyhedron. 18:1999;3281-3288.
8. Rafols C., Roses M., Bosch E. Dissociation constants of several non-steroidal anti-inflammatory drugs in isopropyl alcohol/water mixtures. Anal. Chim. Acta. 350:1997;249-255.
9. Rubino J.T., Berryhill W.S. Effects of solvent polarity on the acid dissociation constants of benzoic acids. J. Pharm. Sci. 75:1986;182-186.