Heterotropic effectors control the hemoglobin function by interacting with its T and R states - A new view on the principle of allostery

Biophysical Chemistry

Volumn 98, Issue 1-2, 2002, Pages 49-63

  Tsuneshige, Antonio ^a,b   Park, SungIck ^a   Yonetani, Takashi ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Allosteric effectors; Allostery; Bohr effect; Human adult hemoglobin; Oxygen equilibrium curves; Root effect

Indexed keywords

DEOXYHEMOGLOBIN; HEMOGLOBIN; OXYGEN; THIOL DERIVATIVE;

ACCURACY; ADULT; ALLOSTERISM; ARTICLE; CIRCULAR DICHROISM; CONTROLLED STUDY; EQUILIBRIUM CONSTANT; HETEROTROPHY; HUMAN; HUMAN CELL; MOLECULAR MODEL; OXYGEN AFFINITY; OXYGENATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; PROTON TRANSPORT; ULTRAVIOLET RADIATION;

ADULT; ALLOSTERIC REGULATION; ALLOSTERIC SITE; BEZAFIBRATE; CARBON MONOXIDE; CHLORIDES; CIRCULAR DICHROISM; CYSTEINE; HEMOGLOBIN A; HUMANS; HYDROGEN-ION CONCENTRATION; KINETICS; OXYGEN; PHYTIC ACID; PROTEIN BINDING; PROTEIN CONFORMATION;

EID: 0037054844     PISSN: 03014622     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0301-4622(02)00084-4     Document Type: Article

References (37)

1. Allosteric linkage
2. The interaction of 2,3-diphosphoglycerate ion human deoxy and oxyhemoglobin
3. On the nature of allosteric transitions: A plausible model
4. Stereochemistry of cooperative effects in haemoglobin
5. The Bohr effect and combination with organic phosphates
6. A mathematical model for structure-function relations in hemoglobin
7. Analysis of the interaction of organic phosphates with hemoglobin
8. Structure-specific model of hemoglobin cooperativity
9. Analysis of proton release in oxygen binding by hemoglobin: Implications for the cooperative mechanism
10. T-state hemoglobin with four ligands bound
11. Bezafibrate lowers oxygen affinity of haemoglobin
12. 0
13. Oxygen equilibrium studies of cross-linked iron-cobalt hybrid hemoglobins. Models for partially ligated intermediates of cobalt hemoglobin
14. The hemoglobin-oxygen equilibrium associated with subunit dissociation
15. Studies on the relations between molecular and functional properties of hemoglobin. V. The influence of temperature on the Bohr effect in human and in horse hemoglobin
16. Nuclear magnetic resonance quadrupole relaxation studies of chloride binding to human oxy- and deoxyhaemoglobin
17. Identification of chloride-binding sites in hemoglobin by nuclear-magnetic-resonance quadrupole-relaxation studies of hemoglobin digests
18. 35Cl NMR study of the release of chloride on oxygen binding to human hemoglobin
19. The chloride effect in human haemoglobin - A new kind of allosteric mechanism
20. The Root effect
21. Stereochemistry of cooperative effects in fish and amphibian haemoglobins
22. Structure of deoxyhaemoglobin of the antartic fish Pagothenia bernacchii with an analysis of the structural basis of the Root effect by comparison of the liganded and unliganded haemoglobin structures
23. Structural basis for the Root effect in haemoglobin
24. Cause of the Root effect in fish haemoglobins
25. The anodic hemoglobin of Anguilla anguilla
26. Purification and functional properties of the hemoglobin components from the rat (Wistar)
27. Evidence for two oxygen linked binding sites for polyanions in dromedary hemoglobin
28. The interaction of chloride ions with human hemoglobin
29. 2 binding by human hemoglobin
30. Interaction of hemoglobin with ions binding of inositol hexaphosphate to human haemoglobin A
31. Effect of 2,3-diphosphoglycerate on the Bohr effect of human adult hemoglobin
32. The interaction of 2,3-diphosphoglycerate with human deoxy- and oxyhemoglobin
33. 31P-NMR studies of the release of diphosphoglyceric acid on carbon monoxide binding to hemoglobin
34. Calorimetric studies of hemoglobin function, the binding of 2,3-diphosphoglycerate and inositol hexaphosphate to human hemoglobin A
35. The reaction of oxygen with hemoglobin and the kinetic basis of the effect of salt on binding of oxygen
36. Analysis of oxygen equilibrium of hemoglobin and control mechanism of organic phosphates
37. Global allostery model of hemoglobin: modulation of O2-affinity, cooperativity, and Bohr effect by heterotropic allosteric effectors,