Rlp7p is associated with 60S preribosomes, restricted to the granular component of the nucleolus, and required for pre-rRNA processing

Journal of Cell Biology

Volumn 157, Issue 6, 2002, Pages 941-951

  Gadal, Olivier ^a,e   Strauss, Daniela ^c   Petfalski, Elisabeth ^b   Gleizes, Pierre Emmanuel ^a   Gas, Nicole ^d   Tollervey, David ^a   Hurt, Ed ^a  

^a Biochemie Zentrum Heidelberg   (Germany)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c Université Paul Sabatier   (France)

^d UNIVERSITY OF HEIDELBERG   (Germany)

^e INSTITUT PASTEUR   (France)

Author keywords

Nucleolus; Preribosome; Ribosome biogenesis; Ribosome export; rRNA processing

Indexed keywords

NUCLEAR PROTEIN; RIBOSOME RNA;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CELL STRUCTURE; CONTROLLED STUDY; EUKARYOTIC CELL; FLUORESCENCE MICROSCOPY; GENE; GENE ISOLATION; GENE MUTATION; IMMUNOELECTRON MICROSCOPY; IN SITU HYBRIDIZATION; LETHAL MUTANT; NONHUMAN; NUCLEOLUS; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN SYNTHESIS; RIBOSOME; RIX9 1 GENE; RLP7P GENE; RNA CLEAVAGE; RNA PROCESSING;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; CELL NUCLEOLUS; CONSERVED SEQUENCE; FUNGAL PROTEINS; GREEN FLUORESCENT PROTEINS; LUMINESCENT PROTEINS; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN STRUCTURE, TERTIARY; RIBOSOMAL PROTEINS; RNA PRECURSORS; RNA PROCESSING, POST-TRANSCRIPTIONAL; RNA, FUNGAL; RNA, RIBOSOMAL; SEQUENCE ALIGNMENT; TEMPERATURE; YEASTS;

ANIMALIA; EUKARYOTA;

EID: 0037054550     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200111039     Document Type: Article

References (39)

1. Isolation and characterization of RAT1: An essential gene of Saccharomyces cerevisiae required for the efficient nucleocytoplasmic trafficking of mRNA
2. Identification of a 60S preribosomal particle that is closely linked to nuclear export
3. Nucleolar changes after microinjection of antibodies to RNA polymerase I into the nucleus of mammalian cells
4. A nucleolar protein related to ribosomal protein L7 is required for an early step in large ribosomal subunit biogenesis
5. Ssf1p prevents premature processing of an early pre60S ribosomal particle
6. Nuclear export of 60S ribosomal subunits depends on Xpo1p and requires a NES-containing factor Nmd3p that associates with the large subunit protein Rpl10p
7. Nuclear pore complexes in the organization of silent telomeric chromatin
8. Nucleolar KKE/D repeat proteins Nop56p and Nop58p interact with Nop1p and are required for ribosome biogenesis
9. Ultrastructural localization of rRNA shows defective nuclear export of preribosomes in mutants of the Nup82p complex
10. Composition and functional characterization of yeast 66s ribosome assembly intermediates
11. Nhp2p and Nop10p are essential for the function of H/ACA snoRNPs
12. r 40.000 protein specific to precursor particles of large ribosomal subunit
13. Protein trans-acting factors involved in ribsome biogenesis in Saccharomyces cerevisiae
14. Two distinct yeast proteins are related to the mammalian ribosomal polypeptide L7
15. Functional compartmentalization of the nucleus in the budding yeast Saccharomyces cerevisiae
16. Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae
17. Maturation of ribosomes requires Noc proteins and is coupled to transport from the nucleolus to the nucleoplasm
18. Detection of fibrillarin in nucleolar remnants and the nucleolar matrix
19. Yeast Pescadillo is required for multiple activities during 60S ribosomal subunit synthesis
20. Immunoelectron microscopic localization of the nucleolar protein B-36 (fibrillarin) during the cell cycle of Physarum polycephalum
21. Localization of U3 RNA molecules in nucleoli of HeLa and mouse 3T3 cells by high resolution in situ hybridization
22. Nuclear mRNA export requires complex formation between Mex67p and Mtr2p at the nuclear pores
23. Nog2p, a putative GTPase associated with pre60S subunits and required for late 60S maturation steps
24. Structure and function of the nucleolus
25. The nucle(ol)ar Tif6p and Efl1p, a novel EF-2 like GTPase, are required for a late cytoplasmic step of ribosome synthesis
26. The nucleolus
27. A temperature sensitive mutant of Saccharomyces cerevisiae defective in prerRNA processing
28. Nucleolar function of the dense crescent in the yeast nucleus
29. A novel complex of nucleoporins, which includes Sec13p and a Sec13p homologue, is essential for normal nuclear pores
30. Structure of the 80S ribosome from Saccharomyces cerevisiae-tRNA-ribosome and subunit-subunit interactions
31. Where, within the nucleolus, are the rRNA genes located?
32. A yeast small nuclear RNA is required for normal processing of preribosomal RNA
33. Temperature-sensitive mutations demonstrate roles for yeast fibrillarin in prerRNA processing, prerRNA methylation, and ribosome assembly
34. Ribosomal precursor particles from yeast
35. Ribosome synthesis in Saccharomyces cerevisiae
36. Human ribosomal protein L7 carries two nucleic acid-binding domains with distinct specificities
37. The economics of ribosome biosynthesis in yeast
38. The structure and biogenesis of yeast ribosomes