Nuclear and cytoplasmic shuttling of TRADD induces apoptosis via different mechanisms

Journal of Cell Biology

Volumn 157, Issue 6, 2002, Pages 975-984

  Morgan, Michael ^a   Thorburn, Jacqueline ^a   Pandolfi, Pier Paolo ^b   Thorburn, Andrew ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

Apoptosis; Leptomycin B; p53; PML; TRADD

Indexed keywords

ADAPTOR PROTEIN; CASPASE INHIBITOR; CELL PROTEIN; PROTEIN BCL XL; PROTEIN P53; PROTEIN TRADD; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL MEMBRANE; CELL NUCLEUS INCLUSION BODY; CONTROLLED STUDY; CYTOPLASM; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROMYELOCYTIC LEUKEMIA; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; ANIMALS; APOPTOSIS; CELL NUCLEUS; CYTOPLASM; FATTY ACIDS, UNSATURATED; FEMALE; HUMANS; MICE; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA; PROTEINS; RECEPTORS, TUMOR NECROSIS FACTOR; SEQUENCE ALIGNMENT; SIGNAL TRANSDUCTION; TNF RECEPTOR-ASSOCIATED DEATH DOMAIN PROTEIN; TNF RECEPTOR-ASSOCIATED FACTOR 1; TUMOR CELLS, CULTURED; TUMOR NECROSIS FACTOR RECEPTOR-ASSOCIATED PEPTIDES AND PROTEINS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0037054549     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200204039     Document Type: Article

References (52)

1. Adenovirus-mediated transfer of wild-type p53 gene sensitizes TNF resistant MCF7 derivatives to the cytotoxic effect of this cytokine: Relationship with c-myc and Rb
2. Wild-type p53 induced sensitization of mutant p53 TNF-resistant cells: Role of caspase-8 and mitochondria
3. Death receptors: Signaling and modulation
4. Resistance of MCF7 human breast carcinoma cells to TNF-induced cell death is associated with loss of p53 function
5. Activation of apoptosis signal-regulating kinase 1 (ASK1) by the adaptor protein Daxx
6. FADD/ MORT1 is a common mediator of CD95 (Fas/APO-1) and tumor necrosis factor receptor-induced apoptosis
7. Phosphorylation of the tumor necrosis factor receptor CD120a (p55) recruits Bcl-2 and protects against apoptosis
8. Apoptotic and necrotic cell death induced by death domain receptors
9. Homeodomain-interacting protein kinase-2 phosphorylates p53 at Set 46 and mediates apoptosis
10. RAIDD is a new "death" adaptor molecule
11. Regulation of p53 activity in nuclear bodies by a specific PML isoform
12. Mitochondria and apoptosis
13. Caspase recruitment domain (CARD)-dependent cytoplasmic filaments mediate bc110-induced NF-κB activation
14. The function of PML in p53-dependent apoptosis
15. A comparison of the activity, sequence specificity, and CRM1-dependence of different nuclear export signals
16. The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation
17. TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex
18. TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways
19. Keratin attenuates tumor necrosis factor-induced cytotoxicity through association with TRADD
20. Hepatocytes sensitized to tumor necrosis factor-α cytotoxicity undergo apoptosis through caspase-dependent and caspase-independent pathways
21. TNF recruits TRADD to the plasma membrane but not the trans-Golgi network, the principal subcellular location of TNF-R1
22. The death domain kinase RIP mediates the TNF-induced NF-kappaB signal
23. Apoptosis signal-regulating kinase 1 controls the proapoptotic function of death-associated protein (Daxx) in the cytoplasm
24. Regulation of p53 by hypoxia: Dissociation of transcriptional repression and apoptosis from p53-dependent transactivation
25. The serine/threonine kinase HIPK2 interacts with TRADD, but not with CD95 or TNF-R1 in 293T cells
26. Cleavage of the death domain kinase RIP by caspase-8 prompts TNF-induced apoptosis
27. The TNF and TNF receptor superfamilies: Integrating mammalian biology
28. Sensitization to death receptor cytotoxicity by inhibition of fas-associated death domain protein (FADD)/caspase signaling. Requirement of cell cycle progression
29. Properties and assembly mechanisms of ND10, PML bodies, or PODs
30. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
31. Defects in the ubiquitin pathway induce caspase-independent apoptosis blocked by Bcl-2
32. An apoptosis signaling pathway induced by the death domain of FADD selectively kills normal but not cancerous prostate epithelial cells
33. PUMA, a novel proapoptotic gene, is induced by p53
34. Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis
35. p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53
36. Bcl-2 prevents caspase-independent cell death
37. Systematic mutational analysis of the death domain of the tumor necrosis factor receptor 1-associated protein TRADD
38. PML induces a novel caspase-independent death process
39. Role of promyelocytic leukemia (PML) protein in tumor suppression
40. FIST/HIPK3. A Fas/fadd-interacting serine/thteonine kinase that induces fadd phosphorylation and inhibits fas-mediated jun nh(2)-terminal kinase activation
41. p53 is involved in tumor necrosis factor-α-induced apoptosis in the human prostatic carcinoma cell line LNCaP
42. Death-effector filaments: Novel cytoplasmic structures that recruit caspases and trigger apoptosis
43. The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex
44. Human Daxx regulates Fas-induced apoptosis from nuclear PML oncogenic domains (PODs)
45. Solution structure of N-TRADD and characterization of the interaction of N-TRADD and C-TRAF2, a key step in the TNFR1 signaling pathway
46. Dual signaling of the Fas receptor: Initiation of both apoptotic and necrotic cell death pathways
47. HIPK2 overexpression leads to stabilization of p53 protein and increased p53 transcriptional activity by decreasing Mdm2 protein levels
48. PML is essential for multiple apoptotic pathways
49. Early lethality, functional NF-kappaB activation, and increased sensitivity to TNF-induced cell death in TRAF2- deficient mice
50. FADD: Essential for embryo development and signaling from some, but not all, inducers of apoptosis
51. The transcriptional role of PML and the nuclear body
52. Promyelocytic leukemia protein (PML) and Daxx participate in a novel nuclear pathway for apoptosis