First highly stereoselective synthesis of fungicide systhane

Organic Letters

Volumn 4, Issue 1, 2002, Pages 55-57

  García Ruano, José L ^a   Cifuentes García, Marta ^a   Martín Castro, Ana M ^a   Rodríguez Ramos, Jesús H ^a  

^a UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

DYES, REAGENTS, INDICATORS, MARKERS AND BUFFERS; FUNGICIDE; NITRILE; SYSTHANE; TRIAZOLE DERIVATIVE;

ARTICLE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; STEREOISOMERISM; SYNTHESIS;

FUNGICIDES, INDUSTRIAL; INDICATORS AND REAGENTS; MAGNETIC RESONANCE SPECTROSCOPY; NITRILES; STEREOISOMERISM; TRIAZOLES;

EID: 0037050540     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol0168723     Document Type: Article

References (22)

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18. 1H NMR δ 7.88 (s, 1H), 7.87 (s, 1H), 7.37 and 7.25 (AA′BB′ system, 4H), 4.61 and 4.49 (AB system, 2H, J 14.5 Hz), 2.16-2.04 (m, 2H), 1.47-1.11 (m, 4H), 0.86 (t, 3H, J 7.0).
19. 3). These new conditions allow for preparation of enantiomerically pure systhane, although in moderate overall yield. The low yield of the hydrocyanating stage at low temperature prompted us to follow the sequence with the enantiomerically enriched (92% de) mixture obtained at room temperature.
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22. Although some stable derivatives of 2 were prepared, none of them showed suitable crystals to be studied by X-ray analysis.