Novel inhibition of porcine pepsin by a substituted piperidine. Preference for one of the enzyme conformers.

The Journal of biological chemistry

Volumn 277, Issue 32, 2002, Pages 28677-28682

  Marcinkeviciene, Jovita ^a   Kopcho, Lisa M ^a   Yang, Tao ^a   Copeland, Robert A ^a   Glass, Brian M ^a   Combs, Andrew P ^a   Falahatpisheh, Nikoo ^a   Thompson, Lorin ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTIC PROTEINASE; ENZYME INHIBITOR; PEPSIN A; PEPSTATIN; PEPTIDE; PIPERIDINE DERIVATIVE;

ANIMAL; ARTICLE; CHEMICAL MODEL; CHEMISTRY; DOSE RESPONSE; DRUG ANTAGONISM; ENZYME SPECIFICITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; KINETICS; PH; PROTEIN BINDING; PROTEIN CONFORMATION; SPECTROFLUOROMETRY; SWINE; TIME;

ANIMALS; ASPARTIC ENDOPEPTIDASES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HYDROGEN-ION CONCENTRATION; KINETICS; MODELS, CHEMICAL; PEPSIN A; PEPSTATINS; PEPTIDES; PIPERIDINES; PROTEIN BINDING; PROTEIN CONFORMATION; SPECTROMETRY, FLUORESCENCE; SUBSTRATE SPECIFICITY; SWINE; TIME FACTORS;

EID: 0037047343     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M203120200     Document Type: Article

References (0)