Brain volumes in familial and non-familial schizophrenic probands and their unaffected relatives

American Journal of Medical Genetics - Neuropsychiatric Genetics

Volumn 114, Issue 6, 2002, Pages 616-625

  McDonald, Colm ^a   Grech, Anton ^a   Toulopoulou, Timothea ^a   Schulze, Katja ^a   Chapple, Ben ^a   Sham, Pak ^a   Walshe, Muriel ^a   Sharma, Tonmoy ^b   Sigmundsson, Thordur ^c   Chitnis, Xavier ^a   Murray, Robin M ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b Stone House Hospital   (United Kingdom)

^c Landspitalinn ^*  (Iceland)

Author keywords

Endophenotypes; Family study; MRI; Obstetric complications; Schizophrenia

Indexed keywords

ADOLESCENT; ADULT; AGED; ARTICLE; BRAIN SIZE; FAMILIAL DISEASE; FAMILY STUDY; FEMALE; GENETIC PREDISPOSITION; GENETIC RISK; HUMAN; MAJOR CLINICAL STUDY; MALE; NERVE CELL DIFFERENTIATION; NUCLEAR MAGNETIC RESONANCE IMAGING; PHENOTYPE; PRIORITY JOURNAL; RELATIVE; SCHIZOPHRENIA; SEX DIFFERENCE; TEMPORAL LOBE; VOLUMETRY; BRAIN; BRAIN DISEASE; CASE CONTROL STUDY; COMPARATIVE STUDY; FAMILY; GENETICS; MIDDLE AGED; PATHOLOGY; PREGNANCY; PREGNANCY COMPLICATION;

ADOLESCENT; ADULT; AGED; BRAIN; BRAIN DISEASES; CASE-CONTROL STUDIES; COMPARATIVE STUDY; FAMILY; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMAN; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGE; PREGNANCY; PREGNANCY COMPLICATIONS; SCHIZOPHRENIA; SUPPORT, NON-U.S. GOV'T; HUMANS; MIDDLE AGED;

EID: 0037044001     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/ajmg.10604     Document Type: Article

References (48)

1. Magnetic resonance imaging of the brain in schizophrenia. The pathophysiologic significance of structural abnormalities
2. Regional brain abnormalities in schizophrenia measured with magnetic resonance imaging
3. A classification of hand preference by association analysis
4. Problems with ratio and proportion measures of imaged cerebral structures
5. Improving stereological estimates for the volume of the structures identified in three-dimensional arrays of spatial data
6. Maternal recall of pregnancy history: Accuracy and bias in schizophrenia research
7. Developmental brain abnormalities in the offspring of schizophrenic mothers. I. Contributions of genetic and perinatal factors
8. Regional gray matter, white matter, and cerebrospinal fluid distributions in schizophrenic patients, their siblings, and controls
9. Fetal hypoxia and structural brain abnormalities in schizophrenic patients, their siblings, and controls
10. Recall of obstetric events by mothers of schizophrenic patients
11. The neurodevelopmental basis of sex differences in schizophrenia
12. Defining the course of brain structural change and plasticity in schizophrenia
13. A family study of the association of increased ventricular size with schizophrenia
14. Third ventricle enlargement and developmental delay in first-episode psychosis: Preliminary findings
15. The Maudsley Family Study IV. Normal planum temporale asymmetry in familial schizophrenia - A volumetric MRI study
16. Alternative phenotypes for the complex genetics of schizophrenia
17. Temporal lobe abnormalities in multigenerational families with schizophrenia
18. The genetics of schizophrenia is the genetics of neurodevelopment
19. The risk for psychiatric disorders in relatives of schizophrenic and control probands: A comparison of three independent studies
20. Magnetic resonance imaging and spectroscopy in offspring at risk for schizophrenia: Preliminary studies
21. Magnetic resonance imaging of brain in people at high risk of developing schizophrenia
22. Brain structure, genetic liability, and psychotic symptoms in subjects at high risk of developing schizophrenia
23. The familial/sporadic distinction as a strategy in schizophrenia research
24. Obstetric complications and schizophrenia: Methodology and mechanisms
25. MRI anatomy of schizophrenia
26. Relationship of obstetric complications and differences in size of brain structures in monozygotic twin pairs discordant for schizophrenia
27. Towards an etiological classification of schizophrenia
28. Sex differences in brain morphology in schizophrenia
29. Diagnostic interview for genetic studies. Rationale, unique features, and training
30. Obstetric complications in schizophrenia and the validity of maternal recall
31. Childhood-onset schizophrenia. Progressive ventricular change during adolescence
32. Cerebral ventricular enlargement in non-genetic schizophrenia: A controlled twin study
33. The genetic basis of cerebral ventricular volume
34. Validity of the familial and sporadic subtypes of schizophrenia
35. Cerebral ventricular size in the offspring of schizophrenic mothers. A preliminary study
36. Thalamic and amygdala-hippocampal volume reductions in first-degree relatives of patients with schizophrenia: An MRI-based morphometric analysis
37. The Maudsley Family Study 1. Structural brain changes on magnetic resonance imaging in familial schizophrenia
38. Brain changes in schizophrenia - Volumetric MRI study of families multiply affected with schizophrenia. The Maudsley Family Study 5
39. Lateral ventricular enlargement in schizophrenic probands and their siblings with schizophrenia-related disorders
40. Schedule for affective disorders and schizophrenia
41. Structural brain abnormalities in patients with schizophrenia and their healthy siblings
42. Anatomical abnormalities in the brains of monozygotic twins discordant for schizophrenia
43. Familial aspects of CT scan abnormalities in chronic schizophrenic patients
44. Can biological markers identify endophenotypes predisposing to schizophrenia?
45. Meta-analysis of regional brain volumes in schizophrenia
46. Structural brain abnormalities in schizophrenia: A family study