Ezrin, a membrane-cytoskeletal linking protein, is highly expressed in atypical endometrial hyperplasia and uterine endometrioid adenocarcinoma

Cancer Letters

Volumn 179, Issue 1, 2002, Pages 79-86

  Ohtani, Kaori ^a   Sakamoto, Hideki ^a   Rutherford, Thomas ^b   Chen, Zhaocong ^b   Kikuchi, Atushi ^a   Yamamoto, Tatsuo ^a   Satoh, Kazuo ^c   Naftolin, Frederick ^b  

^a NIHON UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c NIHON UNIVERSITY   (Japan)

Author keywords

Atypical endometrial hyperplasia; Endometrial adenocarcinoma; Ezrin

Indexed keywords

CYTOSKELETON PROTEIN; EZRIN; LINK PROTEIN;

ADENOCARCINOMA; ADULT; AGED; ARTICLE; CANCER CELL; CANCER GRADING; CANCER GROWTH; CANCER STAGING; CANCER TISSUE; CELL HYPERPLASIA; CELL MEMBRANE; CELLULAR DISTRIBUTION; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOPLASM; CYTOSKELETON; CYTOSOL; DISEASE ASSOCIATION; DISEASE COURSE; ENDOMETRIUM; ENDOMETRIUM CARCINOMA; ENDOMETRIUM HYPERPLASIA; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; METASTASIS; PRECURSOR; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; QUANTITATIVE ANALYSIS; WESTERN BLOTTING;

ADULT; AGED; BLOTTING, WESTERN; CARCINOMA, ENDOMETRIOID; CYTOSKELETAL PROTEINS; ENDOMETRIAL HYPERPLASIA; ENDOMETRIAL NEOPLASMS; ENDOMETRIUM; FEMALE; HUMANS; IMMUNOENZYME TECHNIQUES; MEMBRANE PROTEINS; MIDDLE AGED; PHOSPHOPROTEINS;

EID: 0037042180     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3835(01)00857-6     Document Type: Article

References (22)

1. Moesin, like ezrin, colocalizes with actin in the cortical cytoskeleton in cultured cells, but its expression is more variable
2. Ezrin is concentrated in the apical microvilli of a wide variety of epithelial cells whereas moesin is found primarily in endothelial cells
3. cDNA cloning and sequencing of the protein-tyrosine kinase substrate, ezrin, reveals homology to band 4.1
4. A gene family consisting of ezrin, radixin and moesin
5. The ezrin protein family: Membrane-cytoskeleton interactions and disease associations
6. Ezrin has a COOH-terminal actin site that is conserved in the ezrin protein family
7. Mice heterozygous for a mutation at the Nf2 tumor suppressor locus develop a range of highly metastatic tumors
8. Moesin and CD44 expression in cutaneous melanocytic tumors
9. Mr 75.000 protein, a tumor marker in renal adenocarcinoma, reacting with antibodies to a synthetic peptide based on a cloned human endogenous retroviral nucleotide sequence
10. Ezrin expression in stromal cells of capillary hemangioblastoma, an immunohistochemical survey of brain tumors
11. High levels of ezrin expression by human pancreatic adenocarcinoma cell lines with high metastatic potential
12. Rapid phosphorylation and reorganization of ezrin and spectrin accompany morphological changes induced in A-431 cells by epidermal growth factor
13. The ezrin-like family of tyrosine kinase substrates: Receptor-specific pattern of tyrosine phosphorylation and relationship to malignant transformation
14. A highly expressed 81 kDa protein in immortalized mouse fibroblasts: Its proliferative function and identity with ezrin
15. Metastasis-associated differences in gene expression in a murine model of osteosarcoma
16. Biophysical aspects of the metastatic cascade
17. Ezrin, a membrane-cytoskeletal linking protein, is involved in the process of invasion of endometrial cancer cells
18. Hormones and cancer in humans
19. The behavior of endometrial hyperplasia: A long-term study of "untreated" hyperplasia in 170 patients
20. Induction of tyrosine phosphorylation and translocation of ezrin by hepatocyte growth factor/scatter factor
21. Regulation of cortical structure by the ezrin-radixin-moesin protein family