Production of taxoids with biological activity by plants and callus culture from selected Taxus genotypes

Phytochemistry

Volumn 59, Issue 7, 2002, Pages 725-730

  Parc, Guy ^a   Canaguier, Aurélie ^a   Landré, Pierre ^b   Hocquemiller, Reynald ^c   Chriqui, Dominique ^b   Meyer, Michèle ^a  

^a MUSÉUM NATIONAL D'HISTOIRE NATURELLE   (France)

^b SORBONNE UNIVERSITÉ   (France)

^c CNRS   (France)

Author keywords

10 Deacetylbaccatin III; Biological activity; In vitro culture; Paclitaxel; Taxoids; Taxol; Taxus

Indexed keywords

10 DEACETYLBACCATINE III; 10-DEACETYLBACCATINE III; ANTINEOPLASTIC AGENT; PACLITAXEL; PLANT EXTRACT; TAXOID; TRITERPENE; TUBULIN;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CALLUS CULTURE; CELL STRAIN KB; CHEMICAL COMPOSITION; CHEMISTRY; CYTOLOGY; DRUG ACTIVITY; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG SYNTHESIS; GENETICS; GENOTYPE; HUMAN; HUMAN CELL; HYBRID; METABOLISM; PLANT LEAF; PLANT ROOT; TAXUS; TISSUE CULTURE; TOXICITY TESTING; CULTURE TECHNIQUE;

TAXUS; TAXUS X MEDIA;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; CULTURE TECHNIQUES; GENOTYPE; HUMANS; KB CELLS; PACLITAXEL; PLANT LEAVES; TAXOIDS; TAXUS; TOXICITY TESTS; TRITERPENES;

EID: 0037041056     PISSN: 00319422     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0031-9422(02)00043-2     Document Type: Article

References (24)

1. Taxanes from in vitro cultures of the Himalayan yew Taxus wallichiana
2. Toxicity determined in vitro by morphological alteration and neutral red absorption
3. A highly efficient, practical approach to natural taxol
4. Concentrations of taxol and related taxanes in the needles of different Taxus cultivars
5. Cell culture of Taxus as a source of the antineoplastic drug taxol and related taxanes
6. Improved growth and taxol yield in developing calli of Taxus cuspidata by medium composition modifications
7. Effect of picloram and methyl jasmonate on growth and taxane accumulation in callus culture of Taxus x media Hatfieldii
8. Nutrient requirements of suspension cultures of soybean root cells
9. Initiation and growth of cell lines of Taxus brevifolia
10. Seasonal variation of neutral and basic taxoid contents in shoots of European yew (Taxus baccata)
11. Taxol: Mechanism of action and resistance
12. Rapid isocratic reversed phase HPLC of taxanes on new columns developed specifically for taxol analysis
13. Paclitaxel production in suspension cell cultures of Taxus
14. Relationship between the structures of taxol and baccatin III derivatives and their in vitro action on the disassembly of mammalian brain and Physarum ameobal microtubules
15. Taxoids from cell cultures of Taxus chinensis
16. A revised medium for rapid growth and bioassays with tobacco tissue cultures
17. Microtubule assembly in the absence of added nucleotides
18. Seasonal and tissue variation in taxane concentrations of Taxus brevifolia
19. Production of taxanes by Taxus baccata plant cells
20. A simplified method for the determination of taxanes in yew needles by reversed-phase (C 18) high pressure liquid chromatography
21. Screening of the needles of different yew species and cultivars for paclitaxel and related taxoids
22. Plant antitumor agents VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia
23. Factors affecting the in vitro rapid germination of Taxus embryos and the evaluation of taxol content in the plantlets
24. Tissue cultures of Taxus baccata as a source of 10-deacetylbaccatine III, a precursor for the hemisynthesis of taxol