Highly specific and sensitive liquid chromatography-tandem mass spectrometry method for the determination of 3-desmethylthiocolchicine in human plasma as analyte for the assessment of bioequivalence after oral administration of thiocolchicoside

Journal of Chromatography A

Volumn 949, Issue 1-2, 2002, Pages 71-77

  Sutherland, F C W ^a   Smit, M J ^a   Herbst, L ^a   Els, J ^a   Hundt, H K L ^a   Swart, K J ^a   Hundt, A F ^a  

^a PAREXEL INTERNATIONAL   (United States)

Author keywords

3 Desmethylthiocolchicine; Colchicine; Organosulfur compounds; Thiocolchicoside

Indexed keywords

ACETONITRILE; LIQUID CHROMATOGRAPHY; MASS SPECTROMETERS; MASS SPECTROMETRY; PHARMACOKINETICS;

HUMAN PLASMA;

DRUG PRODUCTS;

3 NORTHIOCOLCHICINE; ACETIC ACID ETHYL ESTER; ACETONITRILE; DRUG METABOLITE; FORMIC ACID; THIOCOLCHICOSIDE; UNCLASSIFIED DRUG;

ACCURACY; ARTICLE; BIOEQUIVALENCE; CONTROLLED STUDY; DEVICE; DRUG BLOOD LEVEL; DRUG DETERMINATION; HUMAN; IONIZATION; LIQUID CHROMATOGRAPHY; PLASMA; PRIORITY JOURNAL; TANDEM MASS SPECTROMETRY;

ADMINISTRATION, ORAL; CHROMATOGRAPHY, LIQUID; COLCHICINE; GABA AGONISTS; HALF-LIFE; HUMANS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; THERAPEUTIC EQUIVALENCY;

EID: 0037040617     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0021-9673(02)00008-0     Document Type: Article

References (5)