Transition from ventricular fibrillation to ventricular tachycardia: A simulation study on the role of Ca2+-channel blockers in human ventricular tissue

Physics in Medicine and Biology

Volumn 47, Issue 23, 2002, Pages 4167-4179

  Bernus, O ^a   Van Eyck, B ^a   Verschelde, H ^a   Panfilov, A V ^b  

^a GHENT UNIVERSITY   (Belgium)

^b UTRECHT UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BIOTECHNOLOGY; CALCIUM; CARDIOLOGY; CELLS; COMPUTER SIMULATION;

VENTRICULAR FIBRILLIATION (VF);

TISSUE;

CALCIUM CHANNEL BLOCKING AGENT; CALCIUM CHANNEL L TYPE; VERAPAMIL;

ANISOTROPY; ARTICLE; CALCIUM CONDUCTANCE; CALCIUM CURRENT; COMPUTER SIMULATION; CONTROLLED STUDY; DRUG EFFECT; HEART STIMULATION; HEART VENTRICLE FIBRILLATION; HEART VENTRICLE TACHYCARDIA; HUMAN; HUMAN TISSUE; MATHEMATICAL MODEL; PRIORITY JOURNAL;

CALCIUM; CALCIUM CHANNEL BLOCKERS; COMPUTER SIMULATION; ELECTROCARDIOGRAPHY; ELECTROPHYSIOLOGY; FOURIER ANALYSIS; HEART VENTRICLES; HUMANS; MODELS, THEORETICAL; TACHYCARDIA, VENTRICULAR; TIME FACTORS; VENTRICULAR FIBRILLATION;

EID: 0037038887     PISSN: 00319155     EISSN: None     Source Type: Journal    
DOI: 10.1088/0031-9155/47/23/304     Document Type: Article

References (38)

1. Amitzur G, Pogatz V, Novikov I, Kaplinsky E and Eldar M 2000 Modulation of ventricular fibrillation in the isolated heart:the role of slow calcium channel activity under continuous perfusion J. Cardiovasc. Pharmacol. 35 16-28
2. Bernus O, Verschelde H and Panfilov A V 2002a Modified ionic models of cardiac tissue for efficient large scale computations Phys. Med. Biol. 47 1947-59
3. Bernus O, Wilders R, Zemlin C W, Verschelde H and Panfilov A V 2002b A computationally efficient electrophysiological model of human ventricular cells Am. J. Physiol. Heart Circ. Physiol. 282 H2296-308
4. Chorro F J, Canoves J, Guerrero J, Mainar L, Sanchis J, Such L and Lopez-Merino V 2000a Alteration of ventricular fibrillation by Flecainide, verapamil, and solatol. An experimental study Circulation 101 1606-15
5. Chorro F J, Canoves J, Guerrero J, Mainar L, Sanchis J, Soria E, Such L M, Rosado A and Lopez-Merino V 2000b Opposite effects of myocardial stretch and verapamil on the complexity of the ventricular fibrillatory pattern:and experimental study Pacing Clin. Electrophysiol. 23 1594-603
6. 2+ dynamics and the stability of ventricular tachycardia Biophys. J. 77 2930-41
7. Clayton R H and Holden A V 2002 Dynamics and interaction of filaments in a computational model of re-entrant ventricular fibrillation Phys. Med. Biol. 47 1777-92
8. Clayton R H and Holden A V 2001 Effect of transmural variations in action potential duration on re-entry in mammalian ventricular myocardium Proc. Physiol. Soc. New Zealand 20 25
9. Clayton R H, Murray A and Campbell R W 1995 Objective features of the surface electrocardiogram during ventricular tachyarrhythmias Eur. Heart J. 16 1115-9
10. Courtemanche M and Winfree A T 1991 Re-entrant rotating waves in a Beeler-Reuter based model of two-dimensional cardiac activity Int. J. Bifurcation Chaos 1 431-44
11. Durrer D, Van Dam R T, Freud G E, Janse M J, Meijler F L and Arzbaecher R C 1970 Total excitation of the isolated human heart Circulation 41 899-912
12. Fenton F and Karma K 1998 Vortex dynamics in three-dimensional continuous myocardium with fibre rotation:filament instability and fibrillation Chaos 8 20-47
13. Garfinkel A, Kim Y H, Voroshilovsky O, Qu Z, Kil J R, Lee M H, Karagueuzian H S, Weiss J N and Chen P S 2000 Preventing ventricular fibrillation by flattening cardiac restitution Proc. Natl. Acad. Sci. USA 97 6061-6
14. Gettes L S, Cascio W E and Sanders W E 1995 Mechanisms of sudden cardiac death Cardiac electrophysiology: From cell to bedside 2nd edn. ed D P Zipes and J Jalife (Philadelphia, PA: Saunders) p 527-38
15. Gray R A, Pertsov A M and Jalife J 1998 Spatial and temporal organization during cardiac fibrillation Nature 392 75-8
16. Guevara M R, Ward A, Shrier A and Glass L 1984 Electrical alternans and period doubling bifurcations IEEE Comp. Cardiol. 562 167-70
17. Holden A V 1998 A last wave from the dying heart Nature 392 20-1
18. Hren R 1996 A realistic model of the human ventricular myocardium: application to the study of ectopic activation PhD Thesis Dalhousie University, Halifax, Canada
19. Karma A 1993 Spiral breakup in model equations of action potential propagation in cardiac tissue Phys. Rev. Lett. 71 1103-6
20. Lee M H, Qu Z, Fishbein G A, Lamp S T, Chang E H, Ohara T, Voroshilovsky O, Kil J R, Hamzei A R, Wang N C, Lin S F, Weiss J N, Garfinkel A, Karagueuzian H S and Chen P S 2002 Patterns of wave break during ventricular fibrillation in isolated swine right ventricle Am. J. Physiol. Heart. Circ. Physiol. 281 H253-65
21. to1 in myocytes isolated from the human right ventricle Am. J. Physiol. Heart Circ. Physiol. 44 H369-77
22. Ks contributes to the longer action potential of the M cell Circ. Res. 75 351-65
23. Luo C and Rudy Y 1991 A model of the ventricular cardiac action potential: depolarization, repolarization and their interaction Circ. Res. 58 1501-26
24. Orlov Y S, Brodsky M A, Orlov M V and Allen B 1997 Near doubling of heart rate after intravenous verapamil for treatment of atrial fibrillation without preexcitation Pacing Clin. electrophysiol. 20 2867-9
25. Panfilov A V 1996 Modeling propagating activity in an anatomical model of the ventricle Computational Biology of the Heart (New York: Wiley) Ch 9
26. Panfilov A V and Holden A V 1990 Self-generation of turbulent vortices in a two-dimensional model of cardiac tissue Phys. Lett. A 147 463-6
27. Plonsey R and Barr R C 1988 Bioelectricity: A Quantitative Approach (New York: Plenum) pp 213-6
28. Qu Z, Weiss J N and Garfinkel A 1999 Cardiac electrical restitution and stability of reentrant spiral waves:a simulation study Am. J. Physiol. Heart Circ. Physiol. 276 H269-83
29. Riccio M L, Koller M L and Gilmour R F Jr 1999 Electrical restitution and spatiotemporal organization during ventricular fibrillation Circ. Res. 84 955-63
30. Rush S and Larsen H 1978 A practical algorithm for solving dynamic membrane equation IEEE Trans. Biomed. Eng. 25 389-439
31. Samie F H, Mandapati R, Gray R A, Watanabe Y, Zuur C, Beaumont J and Jalife J 2000 A mechanism of transition from ventricular fibrillation to tachycardia: effect of calcium channel blockade on the dynamics of rotating waves Circ. Res. 86 684-91
32. Schram G, Pourrier M, Melnyk P and Nattel S 2002 Differential distribution of cardiac ion channel expression as a basis for regional specialization in electrical function. Circ. Res. 90 939-50
33. Stewart A J, Allen J D, Devine A B and Adgey A A 1996 Effects of blockade of fast and slow inward current channels on ventricular fibrillation in the pig heart Heart 76 513-9
34. Trayanova N 2001 Concepts of ventricular defibrillation Phil. Trans. R. Soc. Lond. A 359 1327-37
35. Watanabe Y, Gray R A, Mandapati R, Asano Y and Jalife J 1997 Verapamil converts fibrillation into sustained monomorphic tachycardia in the isolated rabbit heart Pacing Clin. Electrophysiol. 20 1136
36. Wyndham C, Meeran M, Smith T, Engelman R, Levitsky S and Rosen K 1979a Epicardial activation in human left anterior fascicular block Am. J. Cardiol. 44 638-44
37. Wyndham C, Meeran M, Smith T, Saxena A, Engelman R, Levitsky S and Roos J 1979b Epicardial activation of the intact human heart without conduction defect Circulation 59 161-8
38. Wyndham C, Smith T, Meeran M, Mammana R, Levitsky S and Rosen K 1980 Epicardial activation in patients with left bundle branch block Am. J. Cardiol. 44 638-44