New drug delivery system for water-soluble drugs using silicone and its usefulness for local treatment: Application of GCV-silicone to GCV/HSV-tk gene therapy for brain tumor

Journal of Controlled Release

Volumn 84, Issue 1-2, 2002, Pages 15-25

  Maeda, Miho ^a   Moriuchi, Shusuke ^b   Sano, Akihiko ^a   Yoshimine, Toshiki ^b  

^a DAINIPPON SUMITOMO PHARMA CO LTD   (Japan)

^b OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

Author keywords

Ganciclovir; Gene therapy; Glioblastoma; Silicone; Sustained release

Indexed keywords

ANTINEOPLASTIC AGENT; GANCICLOVIR; GANCICLOVIR HERPES SIMPLEX VIRUS THYMIDINE KINASE; SILASTIC; SILICONE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BRAIN TUMOR; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG SOLUBILITY; GENE THERAPY; GLIOBLASTOMA; HERPES SIMPLEX VIRUS; IN VITRO STUDY; MOLECULAR WEIGHT; NONHUMAN; PRIORITY JOURNAL; RAT; SUICIDE GENE;

ALGORITHMS; ANIMALS; ANTINEOPLASTIC AGENTS; BIOCOMPATIBLE MATERIALS; BRAIN NEOPLASMS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; GANCICLOVIR; GLIOSARCOMA; HERPES SIMPLEX; HYDROGEN-ION CONCENTRATION; INFUSION PUMPS, IMPLANTABLE; NEOPLASM TRANSPLANTATION; RATS; SILICONES; SOLUBILITY; THYMIDINE KINASE; TISSUE DISTRIBUTION;

EID: 0037038307     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-3659(02)00236-5     Document Type: Article

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