Efficient liquid-phase synthesis of 2′-hydroxychalcones

Bioorganic and Medicinal Chemistry Letters

Volumn 12, Issue 19, 2002, Pages 2685-2687

  Stoyanov, Edmont V ^a   Champavier, Yves ^b   Simon, Alain ^b   Basly, Jean Philippe ^b  

^a MEDICAL UNIVERSITY OF SOFIA   (Bulgaria)

^b UNIVERSITY OF LIMOGES   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ACETOPHENONE DERIVATIVE; ALDEHYDE DERIVATIVE; CHALCONE DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER GROWTH; CANCER INHIBITION; CELL PROLIFERATION; CELL STRAIN MCF 7; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG SYNTHESIS; HEATING; HIGH TEMPERATURE; HUMAN; HUMAN CELL; MICROWAVE IRRADIATION; POLYMERIZATION;

ALDEHYDES; ANTINEOPLASTIC AGENTS; CHALCONE; CHALCONES; DRUG SCREENING ASSAYS, ANTITUMOR; HEAT; INDICATORS AND REAGENTS; MICROWAVES; TUMOR CELLS, CULTURED;

MINK CELL FOCUS-FORMING VIRUS;

EID: 0037037378     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(02)00553-X     Document Type: Article

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12. In a typical procedure a mixture of 2′-hydroxyacetophenone (1) (1.36 g, 10 mmol) and the corresponding aromatic aldehyde 2 (10 mmol) in 20% KOH/EtOH (10 g) was filled into a 15-mL pressure tube (ALDRICH, with threaded type A plug, length 10.2 cm and additionally provided with a teflon ring) and placed in a beaker (200 mL). After irradiation in an ordinary domestic microwave oven (Moulinex CK3 with rotating plate) at 70 W for 2 min, or heating in oil bath at 132 °C for 3 min, the reaction mixture was cooled and poured into crushed ice water (100 mL). Then concd HCl (10 mL) was added and the reaction mixture was left to stay at 2-3 °C overnight. The separated solid was collected by filtration and recrystallized from methanol.
13. Abstract
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