Differences in individual susceptibility to toxic effects of chemicals determine the dose-response relationship and consequences of setting exposure standards

Toxicology Letters

Volumn 126, Issue 3, 2002, Pages 155-158

  Lutz, Werner K ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL COMPOUND;

CALCULATION; CANCER RISK; CARCINOGENESIS; DOSE RESPONSE; EXPOSURE; GENOTOXICITY; LIFESTYLE; MODULATION; POPULATION; PRIORITY JOURNAL; REDUCTION; REVIEW; STANDARD; TOXICITY; TOXICITY TESTING;

EID: 0037033960     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4274(01)00458-1     Document Type: Article

References (6)

1. Background DNA damage from endogenous and unavoidable exogenous carcinogens: A basis for spontaneous cancer incidence?
2. Additivity to background and linear extrapolation
3. A true threshold dose in chemical carcinogenesis cannot be defined for a population, irrespective of the mode of action
4. Dose-response relationships in chemical carcinogenesis and cancer risk assessment
5. Susceptibility differences in chemical carcinogenesis linearize the dose-response relationship: Threshold doses can be defined only for individuals
6. Threshold dose response for tumor induction by genotoxic carcinogens modeled via cell-cycle delay