Noxious activation of spinal or vagal afferents evokes distinct patterns of fos-like immunoreactivity in the ventrolateral periaqueductal gray of unanaesthetised rats

Brain Research

Volumn 948, Issue 1-2, 2002, Pages 122-130

  Keay, K A ^a   Clement, C I ^a   Matar, W M ^a   Heslop, D J ^a   Henderson, L A ^a   Bandler, R ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Arterial pressure; Haemorrhage; Hypotension; Pain; Shock; Vagus

Indexed keywords

FORMALDEHYDE; PHENYLBIGUANIDE; PROTEIN FOS;

ANIMAL EXPERIMENT; ARTICLE; BRAIN HEMORRHAGE; CARDIOPULMONARY HEMODYNAMICS; EVOKED RESPONSE; HEART CONTRACTION; HEMORRHAGIC SHOCK; HYPOTENSION; IMMUNOREACTIVITY; INJECTION; ISCHEMIA; MALE; MUSCLE SPINDLE AFFERENT NERVE; MUSCLE TISSUE; NOCICEPTIVE STIMULATION; NONHUMAN; PERIAQUEDUCTAL GRAY MATTER; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SENSORY NERVE; SPINAL CORD; SPINAL CORD STIMULATION; SUPERIOR COLLICULUS; THALAMUS VENTRAL NUCLEUS; VAGUS NERVE STIMULATION;

AFFERENT PATHWAYS; ANALGESICS; ANIMALS; BIGUANIDES; BLOOD PRESSURE; CARBON DIOXIDE; CARRAGEENAN; CELL COUNT; FORMALDEHYDE; GENES, IMMEDIATE-EARLY; HEMORRHAGE; HYPOTENSION; INJECTIONS, INTRAMUSCULAR; MALE; MUSCLE, SKELETAL; PAIN MEASUREMENT; PERIAQUEDUCTAL GRAY; PROTO-ONCOGENE PROTEINS C-FOS; RATS; RATS, SPRAGUE-DAWLEY; SPINAL CORD; STIMULATION, CHEMICAL; VAGUS NERVE; WAKEFULNESS;

EID: 0037032101     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(02)02959-1     Document Type: Article

References (64)

1. Bandler R., Keay K.A., Floyd N., Price J.L. Central circuits mediating patterned autonomic activity during active vs. passive emotional coping. Brain Res. Bull. 53:2000;95-104.
2. Bandler R., Price J.L., Keay K.A. Brain mediation of active and passive emotional coping. Mayer E., Saper C., The Science of Body-Mind-Body Interactions. Prog. Brain Res. Vol. 122:2000;331-347.
3. Bandler R., Shipley M.T. Columnar organization in midbrain periaqueductal gray: modules for emotional expression? Trends Neurosci. 17:1994;379-389.
4. Bandler R., Törk I. Midbrain periaqueductal grey region in the cat has afferent and efferent connections with solitary tract nuclei. Neurosci. Lett. 74:1987;1-6.
5. Berberich P., Hoheisel U., Mense S. Effects of a carrageenan-induced myositis on the discharge properties of group III and IV muscle receptors in the cat. J. Neurophysiol. 59:1988;1395-1409.
6. Clement C.I., Keay K.A., Bandler R. Medullary catecholaminergic projections to the ventrolateral periaqueductal gray region activated by halothane anaesthesia. Neuroscience. 86:1998;1273-1284.
7. Clement C.I., Keay K.A., Owler B.K., Bandler R. Common patterns of increased and decreased Fos expression in midbrain and pons evoked by noxious deep somatic and noxious visceral manipulations in the rat. J. Comp. Neurol. 366:1996;495-515.
8. Clement C.I., Keay K.A., Podzbenko K., Gordon B.D., Bandler R. Spinal sources of noxious visceral and noxious deep somatic afferent drive onto ventrolateral periaqueductal gray of the rat. J. Comp. Neurol. 425:2000;323-344.
9. Dickenson A.H., Sullivan A.F. Peripheral origins and central modulations of subcutaneous formalin-induced activity of rat dorsal horn neurons. Neurosci. Lett. 83:1987;207-211.
10. Dickenson A.H., Sullivan A.F. Subcutaneous formalin-induced activity of dorsal horn neurons in the rat: differential response to an intrathecal opiate administered pre or post formalin. Pain. 30:1987;349-360.
11. Evans R.G., Ludbrook J. Chemosensitive cardiopulmonary afferents and the haemodynamic response to simulated haemorrhage in conscious rabbits. Br. J. Pharmacol. 102:1991;533-539.
12. Evans R.G., Ludbrook J., Ventura S. Role of vagal afferents in the haemodynamic response to acute central hypovolaemia in unanaesthetised rabbits. J. Auton. Nerv. Syst. 46:1994;251-260.
13. Finley J.C., Katz D.M. The central organization of carotid body afferent projections to the brainstem of the rat. Brain Res. 572:1983;108-116.
14. Fitzpatrick A.P., Banner N., Cheng A., Yacoub M., Sutton R. Vasovagal reactions may occur after orthotopic heart transplantation. J. Am. Coll. Cardiol. 21:1993;1132-1137.
15. Fu L.W., Longhurst J.C. Reflex pressor response to arterial phenylbiguanide: role of abdominal sympathetic visceral afferents. Am. J. Physiol. 275:1998;H2025-H2035.
16. Gieroba Z.J., MacKenzie L., Willoughby J.O., Blessing W.W. Fos-determined distribution of neurons activated during the Bezold-Jarisch reflex in the medulla oblongata in conscious rabbits and rats. Brain Res. 683:1995;43-50.
17. Giles T.D., Sander G.E. Comparative cardiovascular responses to intravenous capsaicin, phenyldiguanide, veratrum alkaloids and enkephalins in the conscious dog. J. Auton. Pharmacol. 6:1986;1-7.
18. Hammond D., Presley R., Gogas K.R., Basbaum A.I. Morphine or U-50488 suppresses Fos protein-like immunoreactivity in the spinal cord and nucleus tractus solitarius evoked by noxious visceral stimulus in the rat. J. Comp. Neurol. 315:1992;244-253.
19. Herbert H., Saper C.B. Organization of medullary adrenergic and noradrenergic projections to the periaqueductal gray matter in the rat. J. Comp. Neurol. 315:1992;34-52.
20. Herdegen T., Kovary K., Buhl A., Bravo R., Zimmermann M., Gass P. Basal expression of the inducible transcription factors c-jun, junB, junD, c-fos, fosB and KROX-24 in the adult rat brain. J. Comp. Neurol. 354:1995;39-56.
21. Jacobs L., Comroe J.H. Jr. Reflex apnea, bradycardia, and hypotension produced by serotonin and phenyldiguanide acting on the nodose ganglia of the cat. Circ. Res. 29:1971;145-155.
22. Jain S.K., Subramanian S., Julka D.B., Guz A. Search for evidence of lung chemoreflexes in man: study of respiratory and circulatory effects of phenyldiguanide and lobeline. Clin. Sci. 42:1972;163-177.
23. Johnson J.M. Skin, muscle and splanchnic circulations. Scher N., Pawelczyk J., Ludbrook J., Blood Loss and Shock. 1994;133-143 Edward Arnold, London.
24. Jones J.F., Wang Y., Jordan D. Activity of C fibre cardiac vagal efferents in anaesthetized cats and rats. J. Physiol. 507:1998;869-880.
25. Kalia M., Sullivan J.M. Brainstem projections of sensory and motor components of the vagus nerve in the rat. J. Comp. Neurol. 211:1982;248-265.
26. Keay K.A., Bandler R. Deep and superficial noxious stimulation increases Fos like immunoreactivity in different regions of the midbrain periaqueductal gray of the rat. Neurosci. Lett. 154:1993;143-158.
27. Keay K.A., Bandler R. Vascular head pain selectively activates ventrolateral periaqueductal gray in the cat. Neurosci. Lett. 245:1998;58-60.
28. Keay K.A., Clement C.I., Bandler R. The neuroanatomy of cardiac nociceptive pathways: differential representations of superficial and deep pain. Ter Horst G., The Nervous System and the Heart. 2000;303-342 Humana Press, USA.
29. Keay K.A., Clement C.I., Owler B.K., Depaulis A., Bandler R. Convergence of deep somatic and visceral nociceptive information onto a discrete ventrolateral midbrain periaqueductal gray region. Neuroscience. 61:1994;727-732.
30. Keay K.A., Feil K., Gordon B.D., Herbert H., Bandler R. Spinal afferents to functionally distinct PAG columns in the rat: an anterograde and retrograde tracing study. J. Comp. Neurol. 385:1997;207-229.
31. Kwait G.C., Basbaum A.I. Organization of tyrosine hydroxylase- and serotonin-immunoreactive brainstem neurons with axon collaterals to the periaqueductal gray and the spinal cord in the rat. Brain Res. 528:1990;83-94.
32. Lanteri-Minet M., Isnardon P., Pommery J.D., Menetrey D. Spinal and hindbrain structures involved in visceroception and visceronociception as revealed by the expression of Fos, Jun and, Krox-24 Proteins. Neuroscience. 55:1993;737-753.
33. Lanteri-Minet M., Weil-Fugaza J., dePommery J., Menetrey D. Hindbrain structures involved in pain processing as revealed by the expression of c-fos and other immediate early genes. Neuroscience. 58:1994;287-298.
34. Lewis T. Pain. 1942;McMillan, London.
35. Lovick T.A. Integrated activity of cardiovascular and pain regulatory systems: role in adaptive behavioural responses. Prog. Neurobiol. 40:1993;631-644.
36. Ludbrook J. Haemorrhage and shock. Hainsworth R., Mark A., Cardiovascular Reflex Control in Health and Disease. 1993;463-490 Saunders, London.
37. Mense S. Nociception from skeletal muscle in relation to clinical muscle pain. Pain. 54:1993;241-289.
38. Morain P., Abraham C., Portevin B., De Nanteuil G. Biguanide derivatives: agonist pharmacology at 5-hydroxytryptamine type 3 receptors in vitro. Mol. Pharmacol. 46:1994;732-742.
39. Neto F.R. The depolarising action of 5-HT on mammalian non-myelinated nerve fibers. Eur. J. Pharmacol. 49:1978;351-356.
40. Oberg B., Thoren P. Increased activity in left ventricular receptors during hemorrhage or occlusion of caval veins in the cat. A possible cause of the vaso-vagal reaction. Acta Physiol. Scand. 85:1972;164-173.
41. Page I.H., McCubbin J.W. The variable arterial pressure response to serotonin in laboratory animals and man. Circ. Res. 1:1953;354-362.
42. Paxinos G., Watson C. The Rat Brain in Stereotaxic Co-ordinates. 2nd Edition: 1986;Academic Press, Sydney.
43. Rodella L., Rezzani R., Gioia M., Tredici G., Bianchi R. Expression of Fos immunoreactivity in rat supraspinal regions following noxious visceral stimulation. Brain Res. Bull. 47:1998;357-366.
44. Saxena P.R., Villalon C.M. Cardiovascular effects of serotonin agonists and antagonists. J. Cardiovasc. Pharmacol. 15:1990;S17-S34.
45. Schadt J.C., Ludbrook J. Hemodynamic and neurohumoral responses to acute hypovolemia in conscious mammals. Am. J. Physiol. 260:1991;H305-H318.
46. Scharoun S.L., Barone F.C., Wayner M.J., Jones S.M. Vagal and gastric connections to the central nervous system determined by the transport of horseradish peroxidase. Brain Res. Bull. 13:1984;573-583.
47. Scrogin K.E., Veelken R., Johnson A.K. Central methysergide prevents renal sympathoinhibition and bradycardia during hypotensive hemorrhage. Am. J. Physiol. 274:1998;H43-H51.
48. Siegel S. Non-parametric Statistics For the Behavioural Sciences. 1956;McGraw-Hill, New York.
49. Stanfa L.C., Sullivan A.F., Dickenson A.H. Alterations in neuronal excitability and the potency of spinal mu, delta and kappa opioids after carrageenan-induced inflammation. Pain. 50:1992;345-354.
50. Stansfield C.E., Wallis D.I. Properties of visceral primary afferent neurons in the nodose ganglion of the rabbit. J. Neurophysiol. 54:1985;245-260.
51. Takayama K., Suzuki T., Miura M. The comparison of effects of various anesthetics on expression of Fos protein in the rat brain. Neurosci. Lett. 176:1994;59-62.
52. Vardhan A., Kachroo A., Sapru H.N. Excitatory amino acid receptors in the nucleus tractus solitarius mediate the responses to the stimulation of cardio-pulmonary vagal afferent C fiber endings. Brain Res. 618:1993;23-31.
53. Wall P.D. On the relation of injury to pain. Pain. 6:1979;253-264.
54. Wallis D.I., Stansfield C.E., Nash H.L. Depolarising responses recorded from nodose ganglion cells of the rabbit evoked by 5-hydroxytryptamine and other substances. Neuropharmacology. 21:1982;31-40.
55. Whalen E.J., Johnson A.K., Lewis S.J. Functional evidence for the rapid desensitization of 5-HT(3) receptors on vagal afferents mediating the Bezold-Jarisch reflex. Brain Res. 873:2000;302-305.
56. Wiberg M., Blomqvist A. The spinomesencephalic tract in the cat: its cells of origin and termination patterns as demonstrated by intra-axonal transport method. Brain Res. 291:1984;1-18.
57. Wiberg M., Westman J., Blomqvist A. Somatosensory projection to the mesencephalon: an anatomical study in the monkey. J. Comp. Neurol. 264:1987;92-117.
58. Willette R.N., Gatti P., Gertner S.B., Sapru H.N. Pulmonary vagal afferent stimulants in the conscious rat: opioids and phenyldiguanide. Pharmacol. Biochem. Behav. 17:1982;19-23.
59. Xie Q., Itoh M., Miyamoto K., Li L., Takeuchi Y. Cardiac afferents to the nucleus of the tractus solitarius: a WGA-HRP study in the rat. Ann. Thorac. Cardiovasc. Surg. 5:1999;370-375.
60. Yezierski R.P. Spinomesencephalic tract: projections from the lumbosacral spinal cord of the rat, cat and monkey. J. Comp. Neurol. 267:1988;131-146.
61. Yezierski R.P. Somatosensory input to the periaqueductal gray: a spinal relay to a descending control centre. Depaulis A., Bandler R., The Midbrain Periaqueductal Gray Matter: Functional, Anatomical and Neurochemical Organisation. 1991;365-386 Plenum, New York.
62. Yezierski R.P., Broton J.G. Functional properties of spinomesencephalic cells in the upper cervical spinal cord of the cat. Pain. 45:1991;187-198.
63. Yezierski R.P., Mendez C.M. Spinal distribution and collateral projections of rat spinomesencephalic tract cells. Neuroscience. 44:1991;113-130.
64. Zimmermann M. Ethical guidelines for investigations of experimental pain in conscious animals. Pain. 16:1983;109-110.