Nitrated lipids: Defining their bioactivity

Circulation Research

Volumn 91, Issue 5, 2002, Pages 371-372

  Freedman, Jane E ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Leukocytes; Neutrophil; Nitric oxide; Superoxide

Indexed keywords

3 NITROTYROSINE; ADENYLATE CYCLASE; ARACHIDONIC ACID; CALCIUM; CD11B ANTIGEN; CD18 ANTIGEN; CYCLIC GMP; ENZYME INHIBITOR; FORMYLMETHIONYLLEUCYLPHENYLALANINE; GUANYLATE CYCLASE; ICOSANOID; ICOSATRIENOIC ACID; INTERLEUKIN 8; LINOLEIC ACID; LIPID; LIPOPROTEIN; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; NITROGEN; NITROGEN DERIVATIVE; NITROHYDROXYEICOSATRIENOIC ACID; NITROLINOLEATE; PEROXYNITRITE; PHORBOL 12 ACETATE 13 MYRISTATE; REACTIVE OXYGEN METABOLITE; RECEPTOR; SUPEROXIDE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; UNSATURATED FATTY ACID;

ANTIINFLAMMATORY ACTIVITY; BLOOD VESSEL INJURY; BLOOD VESSEL TONE; CALCIUM TRANSPORT; CELL ADHESION; CELL FUNCTION; CELL LYSATE; CELL PROTECTION; CYTOTOXICITY; DEGRANULATION; DRUG ACTIVITY; DRUG EFFECT; EDITORIAL; ENZYME ACTIVATION; HUMAN; INFLAMMATION; LEUKOCYTE ACTIVATION; LIPID METABOLISM; MEDIATOR; MOLECULAR INTERACTION; MUSCLE CELL; NITRATION; NITROSATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; SEPSIS; SHOCK; SIGNAL TRANSDUCTION; SMOOTH MUSCLE RELAXATION; SPECIES; THROMBOCYTE FUNCTION; VASCULAR DISEASE; VASCULAR ENDOTHELIUM;

ANTI-INFLAMMATORY AGENTS; CELL DEGRANULATION; HUMANS; INTEGRINS; LINOLEIC ACID; NEUTROPHILS; NITRO COMPOUNDS; SUPEROXIDES;

EID: 0037031980     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.0000033471.67751.85     Document Type: Editorial

References (13)

1. Nitric oxide reaction with lipid peroxyl radicals spares α-tocopherol during lipid peroxidation: Greater oxidant protection from the pair nitric oxide/α-tocopherol than a-tocopherol/ascorbate
2. Nitric oxide regulation of superoxide and peroxynitrite-dependent lipid peroxidation: Formation of novel nitrogen-containing oxidized lipid derivatives
3. The identification of the allylic nitrite and nitro derivatives of methyl linoleate and methyl linoleate by negative chemical ionization mass spectroscopy
4. The reaction of low levels of nitrogen dioxide with methyl linoleate in the presence and absence of oxygen
5. Vicinal nitrohydroxyeicosatrienoic acids: Vasodilator lipids formed by reaction of nitrogen dioxide with arachidonic acid
6. Nitrolinoleate inhibits platelet activation by attenuating calcium mobilization and inducing phosphorylation of vasodilator-stimulated phosphoprotein through elevation of cAMP
7. Nitrolinoleate inhibits superoxide generation, degranulation, and integrin expression by human neutrophils: Novel antiinflammatory properties of nitric oxide-derived reactive species in vascular cells
8. The intravenous administration of tumor necrosis factor a, interleukin 8 and macrophage-derived neutrophil chemotactic factor inhibits neutrophil migration by stimulating nitric oxide production
9. Inhibition by nitric oxide-donors of human polymorphonuclear leucocyte functions
10. Nitric oxide inhibits neutrophil adhesion to cytokine-activated cardiac myocytes
11. Exogenous nitric oxide increases neutrophil adhesion to cultured human endothelial monolayers through a protein kinase G-dependent mechanism
12. Role of nitric oxide in the failure of neutrophil migration in sepsis
13. 4-integrin: A newly identified pathway of neutrophil recruitment in critically ill septic patients