Synthesis and protein kinase inhibitory activity of balanol analogues with modified benzophenone subunits

Journal of Medicinal Chemistry

Volumn 45, Issue 12, 2002, Pages 2624-2643

  Lampe, John W ^a   Jagdmann Jr , G Erik ^a   Johnson, Mary George ^a   Lai, Yen Shi ^a   Lowden, Christopher T ^a   Lynch, Michael P ^a   Mendoza, José S ^a   Murphy, Marcia M ^a   Wilson, Joseph W ^a   Ballas, Lawrence M ^a   Carter, Kiyomi ^a   Biggers, Christopher K ^a   Darges, James W ^a   Davis, Jefferson E ^a   Hubbard, Frederick R ^a   Stamper, Mark L ^a   Defauw, Jean M ^a   Foglesong, Robert J ^a   Hall, Steven E ^a   Heerding, Julia M ^a   Hollinshead, Sean P ^a   Hu, Hong ^a   Hughes, Philip F ^a   more..

^a ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 [3,5 DIHYDROXY 4 [2 HYDROXY 6 (METHANESULFONYLAMINO)BENZOYL]BENZOYLOXY] 1 (4 HYDROXYBENZAMIDO)CYCLOPENTANE; 2 [3,5 DIHYDROXY 4 [2 HYDROXY 6 (TRIFLUOROMETHANESULFONYLAMINO)BENZOYL]BENZOYLOXY] 1 (4 HYDROXYBENZAMIDO)CYCLOPENTANE; 2 [4 (6 HYDROXY 2 TETRAZOLYLBENZOYL) 3,5 DIHYDROXYBENZOYLOXY] 1 (4 HYDROXYBENZAMIDO)CYCLOPENTANE; 4 [4 (2 HYDROXY 1 NAPHTHOYL) 3,5 DIHYDROXYBENZOYLOXY] 3 (4 HYDROXYBENZAMIDO)PYRROLIDINE; 4 [4 (2 HYDROXY 5,6,7,8 TETRAHYDRO 1 NAPHTHOYL) 3,5 DIHYDROXYBENZOLYOXY] 3 (4 HYDROXYBENZAMIDO)PYRROLIDINE; 4 [4 [N (2 CARBOXYPHENYL)AMINOCARBONYL] 3,5 DIHYDROXYBENZOYLOXY] 3 (4 HYDROXYBENZAMIDO)PYRROLIDINE; [4 (2,6 DIMETHOXYBENZOYL) 3,5 DIHYDROXYBENZOYLOXY] 3 (4 HYDROXYBENZAMIDO)AZEPANE; BALANOL; BENZOPHENONE DERIVATIVE; CYCLIC AMP DEPENDENT PROTEIN KINASE; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; IC 50; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

AZEPINES; BENZOPHENONES; ENZYME INHIBITORS; HUMANS; HYDROXYBENZOIC ACIDS; ISOENZYMES; PROTEIN KINASE C; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037030610     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm020018f     Document Type: Article

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