Polycondensed heterocycles. Part 12: An approach to the synthesis of 2-acetyl-1′-methyl-1,2,3,4-tetrahydrospiro[isoquinoline-1,4′- pyrrolidine]-2′-one

Tetrahedron

Volumn 58, Issue 19, 2002, Pages 3689-3692

  Gemma, Sandra ^a   Campiani, Giuseppe ^a   Butini, Stefania ^a   Morelli, Elena ^a   Minetti, Patrizia ^b   Tinti, Ornella ^b   Nacci, Vito ^a  

^a UNIVERSITY OF SIENA   (Italy)

^b Sigma Tau SpA   (Italy)

Author keywords

2 acetyl 1 methyl 1,2,3,4 tetrahydrospiro isoquinoline 1,4 pyrrolidine 2 one; Cobalt boride selective reduction; Intramolecular trimethylaluminum catalyzed cyclization; Tetrahydroisoquinolines

Indexed keywords

2 ACETYL 1' METHYL 1,2,3,4 TETRAHYDROSPIRO[ISOQUINOLINE 1,4' PYRROLIDINE] 2' ONE; 2 PYRROLIDONE DERIVATIVE; ACETIC ACID DERIVATIVE; ALUMINUM DERIVATIVE; COBALT DERIVATIVE; DIHYDROQUINOLINE DERIVATIVE; ESTER DERIVATIVE; ETHYL (1 AMINOMETHYL 2 ACETYL 1,2,3,4 TETRAHYDRO 1 ISOQUINOLYL)ACETATE; ETHYL (2 ACETYL 1 CYANO 1,2,3,4 TETRAHYDRO 1 ISOQUINOLYL)ACETATE; FUNCTIONAL GROUP; HETEROCYCLIC COMPOUND; UNCLASSIFIED DRUG;

ACYLATION; ARTICLE; CATALYSIS; CHEMICAL MODIFICATION; CYCLIZATION; DRUG SYNTHESIS; POLYMERIZATION; PRIORITY JOURNAL; REDUCTION;

EID: 0037029780     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4020(02)00333-2     Document Type: Article

References (13)