Convenient synthesis of the main dehydrohexapeptide skeleton constituting a macrocyclic antibiotic, berninamycin A

Chemistry Letters

Volumn , Issue 11, 2002, Pages 1098-1099

  Saito, Hirohumi ^a   Yamada, Takahiro ^a   Okumura, Kazuo ^a   Yonezawa, Yasuchika ^a   Shin, Chung Gi ^a  

^a KANAGAWA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

3 HYDROXYVALINE; ANTIBIOTIC AGENT; BERNINAMYCIN A; HEXAPEPTIDE; MACROCYCLIC COMPOUND; UNCLASSIFIED DRUG; VALINE; VINYL DERIVATIVE;

ARTICLE; CYCLIZATION; DEPROTECTION REACTION; DRUG SYNTHESIS; ELIMINATION REACTION; PROTON NUCLEAR MAGNETIC RESONANCE;

EID: 0037027714     PISSN: 03667022     EISSN: None     Source Type: Journal    
DOI: 10.1246/cl.2002.1098     Document Type: Article

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13. BOP: Benzotriazol-l-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate.
14. 3: C, 63.21; H, 7.03; N, 7.37%.
15. 1), 3.85 (s, 3H, OMe), 4.17 (m, 1H, Hy Val's CH), 5.60 (brd, 1H, NH), 5.95, 6.60 (each s, 2H, vinyl's H × 2), 8.79 (br s, 1H, NH).
16. 13: C, 57.66: H, 5.76; N, 12.81%.