Effects of xanthine derivatives on the influx and efflux of doxorubicin in P388 and DOX-resistant P388 leukemia cells

Toxicology Letters

Volumn 135, Issue 1-2, 2002, Pages 137-144

  Sadzuka, Yasuyuki ^a   Egawa, Youichi ^a   Sawanishi, Hiroyuki ^b   Miyamoto, Ken ichi ^c   Sonobe, Takashi ^a  

^a UNIVERSITY OF SHIZUOKA   (Japan)

^b HOKURIKU UNIVERSITY   (Japan)

^c KANAZAWA UNIVERSITY   (Japan)

Author keywords

Biochemical modulator; Doxorubicin; Xanthine derivative; XT 141

Indexed keywords

CYCLOSPORIN A; DOXORUBICIN; FUNCTIONAL GROUP; GLYCOPROTEIN P; UNCLASSIFIED DRUG; VERAPAMIL; XANTHINE DERIVATIVE; XT 107; XT 111; XT 113; XT 115; XT 117; XT 118; XT 130; XT 133; XT 135; XT 139; XT 141; XT 142;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG SENSITIVITY; DRUG UPTAKE; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; LEUKEMIA P 388; MALE; MOLECULAR INTERACTION; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTINEOPLASTIC AGENTS; CALCIUM CHANNEL BLOCKERS; CYCLOSPORINE; DOXORUBICIN; DRUG RESISTANCE, NEOPLASM; DRUG SYNERGISM; ENZYME INHIBITORS; LEUKEMIA P388; MALE; MICE; P-GLYCOPROTEIN; TUMOR CELLS, CULTURED; VERAPAMIL; XANTHINES;

EID: 0037026726     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4274(02)00227-8     Document Type: Article

References (29)

1. Bichat F., Solis-Recebdez G., Poullatin M.G., Poupon M.F., Khayat D., Bastian G. S9788 modulation of P-glycoprotein and multidrug-related protein-mediated multidrug resistance by servier 9788 in doxorubicin-resistant MCF7 cells. Biochem. Pharmacol. 56:1998;497-502.
2. Borst P., Evers R., Kool M., Wijnholds J. The multidrug resistance protein family. Biochim. Biophys. Acta. 1461:1999;347-357.
3. Bruin M.D., Miyake K., Litman T., Robey R., Bates S.E. Reversal of resistance by GF120918 in cell lines expressing the ABC half-transporter, MXR. Cancer Lett. 146:1999;117-126.
4. Castro A.F., Altenberg G.A. Inhibition of the drug transport by genisteine in multidrug-resistant cells expressing P-glycoprotein. Biochem. Pharmacol. 53:1997;89-93.
5. Gervasoni E.L., Fields Z.S., Krishn S., Baker A.M., Rosado M., Thuraisamy K., Hindenberg A.A., Taub N.R. Subcellular distribution of daunorubicin in P-glycoprotein-positive and -negative drug-resistant cell line using laser-assisted confocal microscopy. Cancer Res. 51:1991;4955-4963.
6. Gewirtz D.A. A critical evaluation of the mechanism of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin. Biochem. Pharmacol. 57:1999;727-741.
7. Ishikawa S., Wright D.C., Ishizuka H. GS-X pump is functionally overexpressed in cis-diamminedichloroplatinum (II) resistant human leukemia HL-60 cells and down-regulated by cell differentiation. J. Biol. Chem. 269:1994;29085-29093.
8. Kool M., Haas M., Scheffer G.L., Scheper R.J., Van Eijk M.J.T., Juijin J.A., Baas F., Borst P. Analysis of expression of cMOAT(MRP2), MRP3, MRP4 and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines. Cancer Res. 57:1997;3537-3547.
9. Kusunoki N., Takara K., Tanigawa Y., Yamaguchi A., Ueda K., Komada F., Ku Y., Kuroda Y., Saitoh Y., Okumura K. Inhibitory effects of cyclosporin derivative, SDZ PSC 833, on transport of doxorubicin and vinblastine via P-glycoprotein. Jpn. J. Cancer Res. 89:1998;1220-1228.
10. Leonce S., Pierre A., Anstett M., Perez V., Genton A., Bizzari J.P., Atassi G. Effects of a new triazinoaminopiperidine derivative on adriamycin accumulation and retention in cells displaying P-glycoprotein-mediated multidrug resistance. Biochem. Pharmacol. 44:1992;1707-1715.
11. Miyamoto K., Takagi K., Sakai R., Wakusawa S., Koshiura R., Nadai M., Apichartpichean R., Hasegawa T. Correlation between hydrophobicity of N-alkylxanthine derivatives and their biological activities on guinea-pig isolated tracheal smooth muscle. J. Pharm. Pharmacol. 41:1989;844-847.
12. Miyamoto K., Sakai R., Yamamoto Y., Konno K., Sanae F., Hasegawa T., Takagi K. Selective bronchodilators from 1-(5-oxohexyl)xanthines. J. Pharm. Pharmacol. 44:1992;888-892.
13. Miyamoto K., Yamamoto Y., Kurita M., Sakai R., Konno K., Sanae F., Ohshima T., Takagi K., Hasegawa T., Iwasaki N., Kakiuchi N., Kato H. Bronchodilator activity of xanthine derivatives substituted with functional groups at the 1- or 7-position. J. Med. Chem. 36:1993;1380-1386.
14. Miyamoto K., Sakai R., Kurita M., Ohmae S., Sanae F., Sawanishi H., Hasegawa T., Takagi K. Effects of alkyl substituents of xanthine on phosphodiesterase isoenzymes. Biol. Pharm. Bull. 18:1995;431-434.
15. Priebe W., Krawczyk M., Kuo T.M., Yamane Y., Savaraj N., Ishikawa T. Doxorubicin- and daunorubicin-glutathione conjugates, but not unconjugated drugs, competitively inhibit leukotriene C4 transport mediated by MRP/GS-X pump. Biochem. Biophys. Res. Commun. 247:1998;859-863.
16. Sadzuka Y., Mochizuki E., Takino Y. Caffeine modulates the antitumor activity and toxic side effects of adriamycin. Jpn. J. Cancer Res. 84:1993;348-353.
17. Sadzuka Y., Mochizuki E., Iwazaki A., Hirota S., Takino Y. Caffeine enhances adriamycin antitumor activity in Ehrlich ascites carcinoma-bearing mice. Biol. Pharm. Bull. 18:1995a;159-161.
18. Sadzuka Y., Mochizuki E., Takino Y. Mechanism of caffeine modulation of the antitumor activity of adriamycin. Toxicol. Lett. 75:1995b;39-49.
19. Sadzuka Y., Iwazaki A., Sugiyama T., Sawanishi H., Miyamoto K. 1-Methyl-3-propyl-7-butylxanthine, a novel biochemical modulator, enhances therapeutic efficacy of adriamycin. Jpn. J. Cancer Res. 89:1998a;228-233.
20. Sadzuka Y., Sugiyama T., Hirota S. Modulation of cancer chemotherapy by green tea. Clin. Cancer Res. 153:1998b;153-156.
21. Sadzuka Y., Sugiyama T., Sawanishi H., Miyamoto K. Enhanced efficacy of 1-methyl-3-propyl-7-butylxanthine on the antitumor activity of doxorubicin against doxorubicin-resistant P388 leukemia. Cancer Lett. 138:1999;5-11.
22. Sadzuka Y., Egawa Y., Sugiyama T., Sawanishi H., Miyamoto K., Sonobe T. Effects of 1-methyl-3-propyl-7-butyl-xanthine (MPBX) on idarubicin-induced antitumor activity and bone marrow suppression. Jpn. J. Cancer Res. 91:2000a;651-657.
23. Sadzuka Y., Sugiyama T., Sonobe T. Efficaies of tea components on doxorubicin induced antitumor activity and reversal of multidrug resistance. Toxicol. Lett. 114:2000b;155-162.
24. Sakai R., Konno K., Yamamoto Y., Sanae F., Takagi K., Hasegawa T., Iwasaki N., Kakiuchi M., Kato H., Miyamoto K. Effects of alkyl substitutions of xanthine skeleton on bronchodilation. J. Med. Chem. 35:1992;4039-4044.
25. Sanae F., Ohmae S., Kurita M., Sawanishi H., Takagi K., Miyamoto K. Structure-activity relationships of alkylxanthines: alkyl chain elongation at the N1 or N7-position decreases cardiotopic activity in the isolated guinea-pig heart. Jpn. J. Pharmacol. 69:1995;75-82.
26. Sumizawa T., Chen Z.S., Chuman Y., Seto K., Furusawa T., Haraguchi M., Tani A., Shudo N., Akiyama S. Reversal of multidrug resistant-associated protein-mediated drug resistance by the pyridine analog PAK-104P. Mol. Pharmacol. 51:1977;399-405.
27. Takagi K., Hasegawa T., Kuzuya T., Ogawa K., Watanabe T., Satake T., Miyamoto M., Wakusawa S., Koshiura R. Structure-activity relationship in N3-alkylxanthine derivatives. Jpn. J. Pharmacol. 46:1988;373-378.
28. Tsuruo T., Iida H., Nojiri M., Tsukagoshi S., Sakurai Y. Circumvention of vincristine and adriamycin resistance in vitro and in vivo by calcium influx blocker. Cancer Res. 43:1983;2905-2910.
29. Yusa K., Tsuruo T. Reversal mechanism of multidrug resistance by verapamil: direct binding of verapamil to P-glycoprotein on specific sites and transport of verapamil outward across the plasma membrane of K562/ADM cells. Cancer Res. 46:1989;5002-5006.