Macrocyclic musk compounds - An absence of genotoxicity in the Ames test and the in vivo micronucleus assay

Toxicology Letters

Volumn 135, Issue 1-2, 2002, Pages 155-163

  Abramsson Zetterberg, Lilianne ^a   Slanina, Premysl ^a  

^a NATIONAL FOOD ADMINISTRATION   (Sweden)

Author keywords

Ames test; Macrocyclic musk compounds; Micronucleus test

Indexed keywords

CYCLOPENTADECANOLIDE; ETHYLENE BRASSYLATE; ETHYLENE DODECANEDIOATE; MACROCYCLIC COMPOUND; MUSK; PERFUME; UNCLASSIFIED DRUG;

AMES TEST; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BACTERIAL STRAIN; BLOOD SAMPLING; CONTROLLED STUDY; ERYTHROCYTE; FEMALE; FLOW CYTOMETRY; GENOTOXICITY; IN VIVO STUDY; MALE; MICRONUCLEUS TEST; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; SALMONELLA; TOXICITY TESTING;

ALKANES; ANIMALS; CYCLOPENTANES; DICARBOXYLIC ACIDS; FATTY ACIDS, MONOUNSATURATED; FEMALE; FLOW CYTOMETRY; MALE; MICE; MICRONUCLEUS TESTS; MICROSOMES, LIVER; MUTAGENICITY TESTS; PERFUME; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY;

SALMONELLA;

EID: 0037026713     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4274(02)00257-6     Document Type: Article

References (38)

1. Abramsson-Zetterberg L., Grawé J., Zetterberg G. Flow cytometric analysis of micronucleus induction in mice by internal exposure to 137Cs at very low dose rates. Int. J. Radiat. Biol. 67:1995;29-36.
2. Abramsson-Zetterberg L., Zetterberg G., Grawé J. The time course of micronucleated polychromatc erythrocytes in mouse bone marrow and peripheral blood. Mutat. Res. 350:1996;349-358.
3. Ames B.N., Mc Cann J., Yamasaki E. Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test. Mutat. Res. 31:1975;347-364.
4. Api A.M., Ford R.A., San R.H.C. An evaluation of musk xylene in a battery of genotoxicity tests. Food. Chem. Toxicol. 12:1995;1039-1045.
5. Api A.M., Pfitzer E.A., San R.H.C. An evaluation of genotoxicity tests with musk ketone. Food. Chem. Toxicol. 34:1996;633-638.
6. Busk L., Ahlborg U.G., Albanus L. Inhibition of protein pyrolysate mutagenicity by retinol (vitamin A). Food. Chem. Toxicol. 20:1982;535-539.
7. Cole R.J., Taylor N., Cole J., Arlett C.F. Short terms test for transplacentally active carcinogens. I. Micronucleus formation in fetal and maternal mouse erythroblasts. Mutat. Res. 80:1981;141-157.
8. Cronin E. Photosensitivity to musk ambrette. Contact. Dermatitis. 11:1984;88-92.
9. Davis D.A., Taylor J.M., Jones W.I., Brower J.B. Toxicity to musk ambrette. Toxic. Appl. Pharmac. 10:1967;405.
10. Emig M., Reinhardt A., Mersch-Sundermann V. A comparative study of five nitro musk compounds for genotoxicity in SOS chromotest and Salmonella mutagenicity. Toxicol. Lett. 85:1996;151-156.
11. Eschke, H.D., Traud, J., Dibowski,.J., 1994. Untersuchungen zum verkommen polycycklischen moschus-duftstoffe in verschiedenen umweltkompartimenten. 2. Mitteilung befunde in oberflächen-, abwässern und fischen sowie in waschmittels und kosmetika. UWSF-Z Umweltchem Ökotoxikol 7, 131-138.
12. Eschke H.D., Traud J., Dibowski H.J. Nachweis und Quantifiezierung von polycyclischen Moschus-Dufstoffen mittels Ion-trapGC/MS/MS in Humanfett und Muttermilch. Dtsch. Lebensm-Rundsch. 91:1995;375-379.
13. Ford R.A., Api A.M., Newberne P.M. 90-Day dermal toxicity study and neurotoxicity evaluation of nitromusks in albino rat. Food. Chem. Toxic. 28:1990;55-61.
14. Grawé J., Zetterberg G., Amneus H. Flow-cytometric enumeration of micronucleated erythrocytes in mouse peripheral blood. Cytometry. 13:1992;750-758.
15. Grawé J., Zetterberg G., Amneus H. Effects of extended low dose-rate exposure to 137 Cs detected by flow cytometric enumeration of micronucleated erythrocytes in mouse peripheral blood. Int. J. Rad. Biol. 63:1993;339-347.
16. Grawé J., Abramsson-Zetterberg L., Zetterberg G. Low dose effects of chemicals as assesed by the flow cytometric in vivo micronucleus assay. Mutat. Res. 405:1998;199-208.
17. Hajslova J., Gregor P., Chladkova V., Alterova K. Musk compounds in fish from Elbe River. Organohalogen. Comp. 39:1998;253-256.
18. Hayashi M., Norppa H., Sofuni T., Ishidate M. Jr. Flow cytometric micronucleus test with mouse peripheral erythrocytes. Mutagenesis. 7:1992;257-264.
19. Jenssen D., Ramel C. The micronucleus test as part of a short-term mutagenicity test program for the prediction of carcinogenicity evaluated by 143 agents tested. Mutat. Res. 75:1980;191-202.
20. Kevekordes S., Mersch-Sundermann V., Diez M., Dunkelberg H. In vitro genotoxicity of polycyclic musk fragrances in the micronucleus test. Mutat. Res. 395:1997;145-150.
21. Kevekordes S., Mersch-Sundermann V., Diez M., Bolten C., Dunkelberg H. Genotoxicity of polycyclic musk fragrances in the sister-chromatid exchange test. Anticancer. Res. 18:1998;449-452.
22. Käfferlein H.U., Göen T., Angerer J. Musk xylene: analysis, occurrence, kinetics and toxicology. Crit. Rev. Toxicol. 28:1998;431-476.
23. Lehman-McKeeman L.D., Caudill D., Vassallo J.D., Pearce R.E., Madan A., Parkinson A. Effect of musk xylene and musk ketone on rat hepatic cytochrome P-450 enzymes. Toxicol. Lett. 111:1999;105-115.
24. Liebl B., Ehrenstorfer S. Nitro musks in human milk. Chemosphere. 27:1993;2253-2260.
25. MacGregor J.T., Wehr C.M., Gould D.H. Clastogen-induced micronuclei in peripheral blood erythrocytes: The basis of an improved micronuleus test. Environ. Mutagen. 2:1980;509-514.
26. Maekawa A., Matsushima Y., Onodera H., Shibutani M., Ogasawara H., Kodama Y., Kurokawa Y., Hayashi Y. Long-term toxicity /carcinogenicity of musk xylol in B6C3F1 mice. Food. Chem. Toxicol. 28:1990;5-586.
27. Maron D.M., Ames B.N. Received methods for the Salmonella mutagenicity test. Mutat. Res. 113:1983;173-215.
28. Nair J., Ohshima H., Friesen M., O'Neill I.K., Hautrfeuille A., Bartsch H. Identification, occurrence and mutagenicity in Salmonella typhimurium of two synthetic nitroarenes, musk ambrette and musk xylene, in Indian chewing tobacco and betel quid. Food. Chem. Toxicol. 24:1986;27-31.
29. Natarajan A.T., Obe G. How do in vivo mammalian assays compare to in vitro assays in their ability to detect mutagens? Mutat. Res. 167:1986;189-201.
30. Raugi G.I., Storrs F.J., Larsen W.G. Photoallergic contact dermatitis to men′s perfumes. Contact. Derm. 5:1979;251-260.
31. Rebmann A., Waushkuhn C., Waizenegger W. The importance of musk odorants over the centuries. Dragoco. Report. 2:1998;49-55.
32. Rimkus G.G., Rimkus B., Wolf M. Nitro musks in human adipose tissue and breast milk. Chemosphere. 28:1994;421-432.
33. Rimkus G.G., Butte W., Geyer H.J. Critical considerations on the analysis and bioaccumulation of musk xylene and other synthetic musks in fish. Chemosphere. 35:1997;1497-1507.
34. Rimkus G.G. Polycyclic musk fragrances in the aquatic environmnet. Toxicol. Lett. 111:1999;37-56.
35. Spencer P.S., Bischoff-Fenton M.C., Moreno O.M., Opdyke D.D., Ford R.A. Neurotoxic properties of musk ambrette. Toxic. appl. Pharmac. 75:1984;571-575.
36. Wild D., King M.-T., Gocke E., Eckhardt K. Study of artificial flavouring substances for mutagenicity in the Salmonella/microsome, Basc and micronucleus tests. Fd. Chem. Toxic. 21:1983;707-719.
37. Yahagi T., Nagao M., Seino Y., Matushima T., Sugimura T. Mutagenecities of N-nitrosamines on Salmonella. Mutat. Res. 48:1977;121-129.
38. Yamagishi T., Miyazaki T., Horii S., Kaneko S. Identification of musk xylene and musk ketone in freshwater fish collected from the Tama river, Tokyo. Bull. Environ. Contam. Toxicol. 26:1981;656-662.