Application of a pore-blockage - Cake-filtration model to protein fouling during microfiltration

Biotechnology and Bioengineering

Volumn 79, Issue 3, 2002, Pages 260-270

  Palacio, Laura ^a   Ho, Chia Chi ^b   Zydney, Andrew L ^c  

^a UNIVERSITY OF VALLADOLID   (Spain)

^b University of Delaware   (United States)

^c The Pennsylvania State University   (United States)

Author keywords

Fouling; Membranes; Microfiltration; Protein filtration; Sterile filtration

Indexed keywords

FOULING; LIGHT SCATTERING; MICROFILTRATION; PROTEINS;

PORE BLOCKAGE CAKE-FILTRATION MODEL;

BIOTECHNOLOGY;

BOVINE SERUM ALBUMIN; IMMUNOGLOBULIN G; LYSOZYME; MYOGLOBIN; PEPSIN A; POLYCARBONATE; PROTEIN;

ARTICLE; CONCENTRATION (PARAMETERS); DATA ANALYSIS; FOULING CONTROL; ISOELECTRIC POINT; LIGHT SCATTERING; MEMBRANE; MICROFILTRATION; NONHUMAN; PROTEIN AGGREGATION; PROTEIN MODIFICATION; THEORY;

ADSORPTION; ANIMALS; CATTLE; CHICKENS; COMPUTER SIMULATION; GAMMA-GLOBULINS; HORSES; MACROMOLECULAR SUBSTANCES; MEMBRANES, ARTIFICIAL; MODELS, CHEMICAL; MURAMIDASE; MYOGLOBIN; PEPSIN A; POLYCARBOXYLATE CEMENT; POROSITY; PROTEINS; SENSITIVITY AND SPECIFICITY; SERUM ALBUMIN, BOVINE; SWINE; ULTRAFILTRATION;

BOVINAE;

EID: 0037026236     PISSN: 00063592     EISSN: None     Source Type: Journal    
DOI: 10.1002/bit.10283     Document Type: Article

References (20)

1. Aimar P, Field R. 1992. Limiting flux in membrane separations: A model based on the viscosity dependence of the mass transfer coefficient. Chem Eng Sci 47:579-586.
2. Aimar P, Sanchez V. 1986. Novel approach to limiting phenomena during ultrafiltration of macromolecules. Ind Eng Chem Fund 25:789-798.
3. Belfort G, Davis RH, Zydney AL. 1994. The behavior of suspensions and macromolecular solutions in crossflow microfiltration. J Membr Sci 96:1-58.
4. Chen V. 1998. Performance of partially permeable microfiltration membranes under low-fouling conditions. J Membr Sci 147:265-278.
5. Chu B. 1991. Laser light scattering: Basic principles and practice, 2nd ed. San Diego: Academic Press.
6. Guell C, Davis RH. 1996. Membrane fouling during microfiltration of protein mixtures. J Membr Sci 119:269.
7. Hermans PH, Bredé HL. 1936. Principles of the mathematical treatment of constant-pressure filtration. J Soc Chem Ind 55T:1.
8. Ho CC, Zydney AL. 1999. Theoretical analysis of the effect of membrane morphology on fouling during microfiltration. Sep Sci Tech 34:2461.
9. Ho CC, Zydney AL. 2000. A combined pore blockage and cake filtration model for protein fouling during microfiltration. J Coll Interf Sci 232:389-399.
10. Howell J, Field R, Dengxi W. 1996. Ultrafiltration of high-viscosity solutions: Theoretical developments and experimental findings. Chem Eng Sci 51:1405-1415.
11. Kelly ST, Zydney AL. 1997. Protein fouling during microfiltration: Comparative behavior of different model proteins. Biotechnol Bioeng 55:91-100.
12. Kelly ST, Opong WS, Zydney AL. 1993. The influence of protein aggregates on the fouling of microfiltration membranes during stirred cell filtration. J Membr Sci 80:175-187.
13. Lee DN, Merson RL. 1975. Examination of cottage cheese whey by scanning electron microscopy: relationship to membrane fouling during ultrafiltration. J Dairy Sci 58:1423.
14. Marshall AD, Munro PA, Tragardh G. 1993. The effect of protein fouling in microfiltration and ultrafiltration on permeate flux, protein retention and selectivity: A literature review. Desalination 91:65.
15. Meireles M, Aimar P, Sanchez V. 1991. Albumin denaturation during ultrafiltration: effects of operating conditions and consequences on membrane fouling. Biotechnol Bioeng 38:528.
16. Palecek SP, Zydney AL. 1994. Intermolecular electrostatic interactions and their effect on flux and protein deposition during protein filtration. Biotechnol Prog 10:207-213.
17. Tracey EM, Davis RH. 1994. BSA Fouling of track-etched polycarbonate microfiltration membranes. J Coll Interf Sci 167:104-116.
18. Van den Berg GB, Smolders CA. 1990. Flux decline in ultrafiltration processes. Desalination 77:101-133.
19. Wu DX, Howell JA, Field RW. 1999. Critical flux measurement for model colloids. J Membr Sci 152:89.
20. Zeman LJ, Zydney AL. 1996. Microfiltration and ultrafiltration: Principles and applications. New York: Marcel Dekker.