A solid-phase approach towards the synthesis of PDE5 inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 12, Issue 15, 2002, Pages 1973-1976

  Beer, David ^a   Bhalay, Gurdip ^a   Dunstan, Andrew ^a   Glen, Angela ^a   Haberthuer, Sandra ^a   Moser, Heinz ^a  

^a NOVARTIS HORSHAM RESEARCH CENTRE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CHLORIDE; PHOSPHODIESTERASE INHIBITOR; PHOSPHODIESTERASE V INHIBITOR; UNCLASSIFIED DRUG; XANTHINE DERIVATIVE; CGMP BINDING, CGMP SPECIFIC 3',5' CYCLIC NUCLEOTIDE PHOSPHODIESTERASE; CGMP-BINDING, CGMP-SPECIFIC 3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE; CYCLIC GMP PHOSPHODIESTERASE; DYES, REAGENTS, INDICATORS, MARKERS AND BUFFERS; PHOSPHODIESTERASE; XANTHINE;

ARTICLE; DRUG ACTIVITY; DRUG PURITY; DRUG SYNTHESIS; ENZYME INHIBITION; SOLID; CHEMISTRY; COMBINATORIAL CHEMISTRY; FACTUAL DATABASE; METABOLISM; NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

COMBINATORIAL CHEMISTRY TECHNIQUES; DATABASES, FACTUAL; INDICATORS AND REAGENTS; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PHOSPHODIESTERASE INHIBITORS; PHOSPHORIC DIESTER HYDROLASES; STRUCTURE-ACTIVITY RELATIONSHIP; XANTHINE; 3',5'-CYCLIC-GMP PHOSPHODIESTERASE;

EID: 0037025446     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(02)00296-2     Document Type: Article

References (19)