Enantioselective stereoinversion in the kinetic resolution of rac-sec-alkyl sulfate esters by hydrolysis with an alkylsulfatase from Rhodococcus ruber DSM 44541 furnishes homochiral products

Angewandte Chemie - International Edition

Volumn 41, Issue 21, 2002, Pages 4052-4054

  Pogorevc, Mateja ^a   Kroutil, Wolfgang ^a   Wallner, Sabine R ^a   Faber, Kurt ^a  

^a UNIVERSITY OF GRAZ   (Austria)

Author keywords

Alkylsultatase; Biotransformations; Configuration inversion; Hydrolysis; Sulfate ester

Indexed keywords

CATALYSIS; ESTERS; HYDROLYSIS;

KINETIC RESOLUTIONS;

STEREOCHEMISTRY;

ALKYL SULFATASE; ESTER; SULFATASE; SULFATE; UNCLASSIFIED DRUG;

ARTICLE; BIOTRANSFORMATION; CATALYSIS; CHEMISTRY; CHIRALITY; CONFORMATION; ENANTIOSELECTIVITY; ENZYMOLOGY; HYDROLYSIS; KINETICS; METABOLISM; MOLECULAR RECOGNITION; RACEMIC MIXTURE; RHODOCOCCUS; STEREOCHEMISTRY; STEREOISOMERISM;

ESTERS; HYDROLYSIS; KINETICS; MOLECULAR CONFORMATION; RHODOCOCCUS; STEREOISOMERISM; SULFATASES; SULFATES;

EID: 0037021012     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-3773(20021104)41:21<4052::AID-ANIE4052>3.0.CO;2-W     Document Type: Article

References (13)

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5. For the deracemization of epoxides see: a) W. Kroutil, M. Mischitz, K. Faber, J. Chem. Soc. Perkin Trans. 1 1997. 3629-3636; b) R. V. A. Orru, S. F. Mayer, W. Kroutil, K. Faber, Tetrahedron 1998, 54, 859-874.
6. For the deracemization of epoxides see: a) W. Kroutil, M. Mischitz, K. Faber, J. Chem. Soc. Perkin Trans. 1 1997. 3629-3636; b) R. V. A. Orru, S. F. Mayer, W. Kroutil, K. Faber, Tetrahedron 1998, 54, 859-874.
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11. Protein purification and full biochemical characterization will be published in due course.
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