Using molecular symmetry to form new drugs: Hydroxymethyl-substituted 3,9-diazatetraasteranes as the first class of symmetric MDR modulators

Angewandte Chemie - International Edition

Volumn 41, Issue 19, 2002, Pages 3623-3625

  Hilgeroth, Andreas ^a   Molnár, Jósef ^b   De Clercq, Eric ^c  

^a MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^b UNIVERSITY OF SZEGED   (Hungary)

^c REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

Cage compounds; MDR modulators; Medicinal chemistry; Photochemistry; Structure activity relationships

Indexed keywords

HYDROGEN BONDS; ORGANIC COMPOUNDS; PROTEINS; SUBSTITUTION REACTIONS; TUMORS;

GLYCOPROTEINS;

DRUG PRODUCTS;

3,9 DIAZATETRAASTERANE DERIVATIVE; ANTINEOPLASTIC AGENT; CYCLOSPORIN A; GLYCOPROTEIN P; HETEROCYCLIC COMPOUND; MULTIDRUG RESISTANCE PROTEIN; P GLYCOPROTEINS; UNCLASSIFIED DRUG; VERAPAMIL;

ANIMAL; ARTICLE; CANCER RESISTANCE; CELL CULTURE; CHEMICAL MODIFICATION; CHEMICAL STRUCTURE; CHEMISTRY; DIMERIZATION; DRUG DESIGN; DRUG PROTEIN BINDING; DRUG RESISTANCE; DRUG STRUCTURE; DRUG SYNTHESIS; METABOLISM; MOUSE; MULTIDRUG RESISTANCE; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANIMALS; ANTINEOPLASTIC AGENTS; DRUG DESIGN; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; HETEROCYCLIC COMPOUNDS; MICE; MOLECULAR STRUCTURE; P-GLYCOPROTEINS; TUMOR CELLS, CULTURED;

EID: 0037020333     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-3773(20021004)41:19<3623::AID-ANIE3623>3.0.CO;2-V     Document Type: Article

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