Incorporation of an amide into 5-phosphonoalkyl-6-D-ribitylaminopyrimidinedione lumazine synthase inhibitors results in an unexpected reversal of selectivity for riboflavin synthase vs lumazine synthase

Journal of Organic Chemistry

Volumn 67, Issue 20, 2002, Pages 6871-6877

  Cushman, Mark ^a   Yang, Donglai ^a   Mihalic, Jeffrey T ^a   Chen, Jinhua ^a   Gerhardt, Stefan ^b,c   Huber, Robert ^c   Fischer, Markus ^b   Kis, Klaus ^b   Bacher, Adelbert ^b  

^a PURDUE UNIVERSITY   (United States)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^c MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

INTERMEDIATES;

CATALYSIS; ENZYMES; ESCHERICHIA COLI;

ENZYME INHIBITION;

AMIDE; LUMAZINE SYNTHASE; PYRIMIDINE DERIVATIVE; RIBOFLAVIN SYNTHASE; SCHIFF BASE; UNCLASSIFIED DRUG;

ARTICLE; BACILLUS SUBTILIS; CHEMICAL ANALYSIS; CHEMICAL REACTION; ENZYME INHIBITION; ENZYME SYNTHESIS; ESCHERICHIA COLI; MOLECULAR MODEL; NONHUMAN; REACTION ANALYSIS;

AMIDES; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; ENZYME INHIBITORS; ESCHERICHIA COLI; KINETICS; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MULTIENZYME COMPLEXES; PROTEIN CONFORMATION; PTERIDINES; PYRIMIDINONES; RIBOFLAVIN SYNTHASE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037019984     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo020144r     Document Type: Article

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