Organic osmolytes betaine, sorbitol and inositol are potent inhibitors of erythrocyte membrane ATPases

Life Sciences

Volumn 71, Issue 20, 2002, Pages 2413-2424

  Moeckel, Gilbert W ^a   Shadman, Ramin ^b   Fogel, Joy M ^b   Sadrzadeh, Sayed M H ^b  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSITY OF ARIZONA   (United States)

Author keywords

ATPase; Hypertonicity; Membranes; Osmolytes; Red blood cells

Indexed keywords

ADENOSINE TRIPHOSPHATASE; ADENOSINE TRIPHOSPHATASE (CALCIUM); ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ADENOSINE TRIPHOSPHATASE INHIBITOR; BETAINE; INOSITOL; SORBITOL;

ARTICLE; CELL PROTECTION; COMPARATIVE STUDY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENCY; ENZYME INHIBITION; ERYTHROCYTE MEMBRANE; HEMOLYSIS; HUMAN; HUMAN CELL; MODEL; OSMOTIC STRESS; PHYSIOLOGY; SERUM;

ADENOSINE TRIPHOSPHATASES; BETAINE; ENZYME INHIBITORS; ERYTHROCYTE MEMBRANE; INOSITOL; OSMOLAR CONCENTRATION; SORBITOL; UREA;

ANIMALIA;

EID: 0037019911     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0024-3205(02)02035-0     Document Type: Article

References (30)

1. Macknight A.D.C. Principles of cell volume regulation. Renal Physiology & Biochemistry. 11:1988;114-141.
2. Yancey P.H., Clark M.E., Hand S.C.et al. Living with water stress: evolution of osmolytes systems. Science. 217:1982;1214-1222.
3. Somero G.N., Yancey P.H. Osmolytes and cell volume regulation: physiological and evolutionary principles. Hoffmann J.F., Jamieson J.D. Handbook of Physiology, Section 14: Cell Physiology. 1997;441-484 Oxford University Press, New York.
4. Jamison R.L., Kriz W. Urinary concentrating mechanism: structure and function. 1982;Oxford University Press, New York.
5. Beck F.X., Dörge A., Thurau K., Guder W.G. Cell osmoregulation in the countercurrent system of the renal medulla: the role of organic osmolytes. Beyenbach K.W. Cell Volume Regulation. 1990;132-158 Karger, Basel.
6. Kinne R.K.H., Boese S.H., Kinne-Safran E.et al. Osmoregulation in the renal papilla: Membranes, messengers and molecules. Kidney International. 49:1996;1686-1689.
7. Garcia-Perez A., Burg M.B. Renal medullary organic osmolytes. Physiological Reviews. 71:1991;1081-1115.
8. Ellory J.C., Gibson J.S., Stewart G.W. Pathophysiology of abnormal cell volume in human red cells. Lang F. Cell Volume Regulation. Contrib. Nephrol. vol. 123:1998;220-239 Basel, Karger.
9. Chien S. Red cell deformability and its relevance to blood flow. Annual Revue of Physiology. 49:1970;177-192.
10. Eaton W.A., Hofrichter J. Hemoglobin S gelation and sickle cell disease. Blood. 70:1987;1245-1266.
11. Jensen F.B. Regulatory volume decrease in carp red blood cells: mechanisms and oxygenation-dependency of volume-activated potassium and amino acid transport. Journal of Experimental Biology. 198:1995;155-165.
12. Haynes J.K., Goldstein L. Volume-regulatory amino acid transport in erythrocytes of the little skate, Raja erinacea. American Journal of Physiology. 265:1993;R173-R179.
13. Goldstein L., Davis E.M. Taurine, betaine and inositol share a volume sensitive transporter in skate erythocyte cell membrane. American Journal of Physiology. 267:1994;R426-R431.
14. Lindner A., Vanholder R., De Smet R.et al. HPLC fractions of human uremic plasma inhibit the RBC membrane calcium pump. Kidney International. 51:1997;1042-1052.
15. Carafoli E. Calcium pump of the plasma membrane. Physiological Reviews. 71:1991;129-153.
16. Post R.L. Seeds of sodium, potassium ATPase. Annual Review of Physiolgy. 51:1989;1-15.
17. +-ATPase. Journal of Bioenergy and Biomembranes. 24:1992;249-261.
18. Vincenzi F.F., Hinds T.R. Plasma membrane calcium transport and membrane-bound enzymes. Martonosi A. The Enzymes of Biological Membranes. Membrane Transport. vol. 3:1976;261-281 Plenum Press, New York.
19. 2+ pump. Biochemistry. 29:1990;355-365.
20. 2+)-ATPase activity of human erythrocyte membranes by hemolysis in isoosmotic imidazole buffer. I. General properties of variously prepared membranes and the mechanism of the isoosmotic imidazole effect. Biochimica et Biophysica Acta. 471:1977;49-58.
21. Sadrzadeh S.M.H., Vincenzi F.F., Hinds T.R. Simultaneous Measurement of Multiple Membrane ATPases in Microtiter Plates. Journal of Pharmacological and Toxicological Methods. 30:1993;103-110.
22. Smith P.K., Krohn R.I., Hermanson G.T.et al. Measurement of protein using bicinchoninic acid. Analytical Biochemistry. 150:1985;76-85.
23. Lindmark K., Engstrom K.G. D-glucose additive protects against osmotic-induced decrease in erythrocyte filterability. Scandinavian Journal of Clinical Laboratory Investigation. 60:2000;473-482.
24. 2+-ATPase from kidney proximal tubule. Journal of Biological Chemistry. 266:1991;10324-10330.
25. 2+ in sorbitol release from rat inner medullary collecting duct (IMCD) cells under hypoosmotic stress. Biochemical Biophysical Research Communications. 170:1990;563-568.
26. 2+ influx during regulatory volume decrease in IMCD cells. American Journal of Physiology. 267:1994;F130-F138.
27. Czekay R.P., Kinne-Saffran E., Kinne R.K.H. Membrane traffic and sorbitol release during osmo- and volume regulation in isolated rat renal inner medullary collecting duct. European Journal of Cell Biology. 63:1994;20-31.
28. Kinne-Saffran E., Pfaff Ch., Kinne R.K.H. Regulation of sorbitol release in a cell line derived from the thick ascending limb of Henle's loop (TALH). Journal of American Society of Nephrology. 6:1995;364.
29. Kirk K. Swelling-activated organic osmolyte channels. Journal of Membrane Biology. 158:1997;1-16.
30. Law R.O., Burg M.B. The role of organic omolytes in the regulation of mammalian cell volume. Gilles R., Hoffman E.K., Bolis L. Volume and Osmolality Control in Animal Cells. 1991;189-225 Springer, Berlin.