Use of response surface methodology to optimize culture medium for production of lovastatin by Monascus ruber

Enzyme and Microbial Technology

Volumn 30, Issue 7, 2002, Pages 889-894

  Chang, Yaw Nan ^a   Huang, Jen Chang ^a   Lee, Chih Chen ^b   Shih, Ing Lung ^a   Tzeng, Yew Min ^c  

^a DA YEH UNIVERSITY   (Taiwan)

^b Tanque Co   (Taiwan)

^c CHAOYANG UNIVERSITY OF TECHNOLOGY   (Taiwan)

Author keywords

Fermentation; Lovastatin production; Medium optimization; Monascus ruber; Response surface methodology

Indexed keywords

FERMENTATION; GLUCOSE; GLYCEROL;

RESPONSE SURFACE METHODOLOGY;

ENZYMES;

GLUCOSE; GLYCEROL; MEVINOLIN; PEPTONE;

ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CULTURE MEDIUM; DRUG SYNTHESIS; FERMENTATION; FUNGUS; FUNGUS CULTURE; LIQUID; METHODOLOGY; MONASCUS RUBER; NONHUMAN; POWDER; RICE; SOLID STATE; SURFACE PROPERTY;

MONASCUS; MONASCUS RUBER;

EID: 0037018875     PISSN: 01410229     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0141-0229(02)00037-6     Document Type: Article

References (27)

1. Mevinolin, a highly potent competitive inhibitor of hydroxymethyl-glutaryl coenzyme A reductase and chlosterol lowering agent
2. Inhibitory effects on lipid metabolism in cultured cells of ML-236B, a potent inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase
3. Progress in understanding the LDL receptor and HMG-CoA reductase, two membrane proteins that regulate the plasma cholesterol
4. The lipid research clinics coronary primary prevention trial results, I. Reduction in incidences of coronary heart disease
5. The relationship of reduction in incidence of coronary heart disease to cholesterol lowering
6. Lovastatin induces growth inhibition and apoptosis in human malignant glioma cells
7. Selective inhibition of primary acute myeloid leukemia cell growth by lovastatin
8. A new hypocholesterolemic agent produced by a Monascus species
9. Productivity of monacolin K (mevinolin) in the genus Monascus (in Japanese)
10. Discovery, biochemistry and biology of lovastatin
11. The synthesis of compactin (ML-236B) and monacolin K in fungi
12. Production of lovastatin, an inhibitor of cholesterol accumulation in human
13. Production of lovastatin by a wild strain of Aspergillus terreus
14. Secondary metabolites of the fungus Monascus: A review
15. Dihydromonacolin L and monacolin X, new metabolites that inhibit cholesterol biosynthesis
16. Response surface model for predicting the effects of temperature, pH, sodium chloride content, sodium nitrite concentration and atmosphere on the growth of Listeria monocutogenes
17. Optimization of a culture medium for increased xylanase production by a wild strain of Schizophyllum commune
18. Optimization of carrot dehydration process using response surface methodology
19. Maximization of lipid production by Rhodotroula gracilis CFR-1 using response surface methodology
20. Optimizing alcohol production from whey using computer technology
21. On the experimental attainment of optimum conditions
22. Effect of glycerin on monacolin K production by Monascus ruber
23. Monascus purpureus-fermented rice (red yeast rice): A natural food product that lowers blood cholesterol in animal models of hypercholesterolema
24. Cholesterol lowering effects of a proprietary Chinese red-yeast-rice dietary supplement