Solution- and solid-phase synthesis of enantiomerically pure spiro oxindoles

Tetrahedron Letters

Volumn 43, Issue 49, 2002, Pages 8981-8983

  Ganguly, A K ^a   Seah, N ^a   Popov, V ^a   Wang, C H ^a   Kuang, R ^b   Saksena, A K ^b   Pramanik, B N ^b   Chan, T M ^b   McPhail, A T ^c  

^a STEVENS INSTITUTE OF TECHNOLOGY   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

^c DUKE UNIVERSITY   (United States)

Author keywords

1:3 dipolar cycloaddition reactions; Oxindoles

Indexed keywords

OXINDOLE;

AQUEOUS SOLUTION; ARTICLE; CYCLOADDITION; DRUG SYNTHESIS; ENANTIOMER; ENANTIOSELECTIVITY; SOLID; X RAY CRYSTALLOGRAPHY;

EID: 0037010828     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(02)02184-6     Document Type: Article

References (7)

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5. All the compounds described in this paper were crystalline. Molecular weights were determined using high resolution mass spectrometry. NMR spectra were consistent with the assigned structures and further confirmed using NOE and HMBC experiments.
6. w=0.055) over 2334 reflections with I>2.0σ(I). Crystallographic data (excluding structure factors) have been deposited with the Cambridge Crystallographic Data Centre, deposition number CCDC 188917. Copies of the data can be obtained, free of charge, on application to CCDC, 12 Union Road, Cambridge, CB2 1EZ, UK [fax: +44 (0)1223 336033 or e-mail: deposit@ccdc.cam.ac.uk].
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