Cellular mechanisms of inhibition of superoxide anion generation in rat neutrophils by the synthetic isoquinoline DMDI

European Journal of Pharmacology

Volumn 434, Issue 1-2, 2002, Pages 9-16

  Wang, Jih Pyang ^a   Chang, Ling Chu ^a   Raung, Shue Ling ^a   Hsu, Mei Feng ^b   Chen, Chi Ming ^c  

^a TAICHUNG VETERANS GENERAL HOSPITAL   (Taiwan)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

^c TAIPEI MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Ca2+ concentration, cellular free; DMDI (1 (3 ,4 dimethoxybenzyl) 6,7 dichloroisoquinoline); MAP (Mitogen activated protein) kinase; Neutrophil; Phospholipase D; Respiratory burst; Signal transduction

Indexed keywords

1 (3',4' DIMETHOXYBENZYL) 6,7 DICHLOROISOQUINOLINE; ALCOHOL; CALCIUM; CYCLIC AMP; DIHYDROXYFUMARIC ACID; FORMYLMETHIONYLLEUCYLPHENYLALANINE; FORSKOLIN; ISOQUINOLINE DERIVATIVE; KT 5720; PHOSPHATIDIC ACID; PHOSPHATIDYLETHANOLAMINE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOLIPASE D; SCAVENGER; SUPEROXIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; AUTOOXIDATION; CELL FREE SYSTEM; CELL LEVEL; CELLULAR DISTRIBUTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG POTENCY; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; EXTRACELLULAR CALCIUM; IC 50; IMMUNOBLOTTING; NEUTROPHIL; NONHUMAN; OXYGEN CONSUMPTION; PRIORITY JOURNAL; RAT; RESPIRATORY BURST; SIGNAL TRANSDUCTION; SPIKE WAVE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; ANTI-INFLAMMATORY AGENTS; CALCIUM; CYCLIC AMP; ISOQUINOLINES; MITOGEN-ACTIVATED PROTEIN KINASES; N-FORMYLMETHIONINE LEUCYL-PHENYLALANINE; NEUTROPHILS; PHOSPHOLIPASE D; PHOSPHORYLATION; RATS; RATS, SPRAGUE-DAWLEY; SUPEROXIDES;

EID: 0037005734     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(01)01536-9     Document Type: Article

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