Effects of ReN1869, a CNS-available antihistamine, on capsaicin- and histamine-induced neurogenic inflammation in healthy subjects

Drug Development Research

Volumn 57, Issue 4, 2002, Pages 193-199

  Thomsen, Mikael S ^a   Hansen, Anker J ^a   Olsen, Uffe B ^a   Reeh, Peter ^b   Ingwersen, Steen ^a   Schaffler, Klaus ^c   Seibel, Klaus ^c  

^a NOVO NORDISK A S   (Denmark)

^b UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^c Human Pharmacodynamic Research   (Germany)

Author keywords

Analgesic effect; Antihistaminergic effect; Capsaicin hyperalgesia; Laser; ReN1869; Somatosensory evoked potentials

Indexed keywords

1 [3 (10,11 DIHYDRO 5H DIBENZO[A,D]CYCLOHEPTEN 5 YLIDENE)PROPYL] 3 PIPERIDINECARBOXYLIC ACID; ANTIHISTAMINIC AGENT; CAPSAICIN; HISTAMINE; HISTAMINE H1 RECEPTOR; HISTAMINE H1 RECEPTOR ANTAGONIST; PLACEBO; REN1869; UNCLASSIFIED DRUG;

ADULT; ALLODYNIA; ANALGESIC ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ANTINOCICEPTION; ARTICLE; CLINICAL TRIAL; COLORIMETRY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG HALF LIFE; EVOKED SOMATOSENSORY RESPONSE; HUMAN; HUMAN EXPERIMENT; HYPERALGESIA; MALE; NEUROGENIC INFLAMMATION; NOCICEPTIVE STIMULATION; NORMAL HUMAN; PAIN; PAIN ASSESSMENT; PAIN THRESHOLD; PRURITUS; RANDOMIZED CONTROLLED TRIAL; URTICARIA;

EID: 0037000944     PISSN: 02724391     EISSN: None     Source Type: Journal    
DOI: 10.1002/ddr.10150     Document Type: Article

References (24)

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