Lactoferrin: Mechanism of action, clinical significance and therapeutic relevance

Acta Biomedica de l'Ateneo Parmense

Volumn 73, Issue 5-6, 2002, Pages 71-73

  Cavestro, Giulia Martina ^a   Iori, Veronica ^a   Dal Bò, Nadia ^b   Franzè, Angelo ^d   Ingegnoli, Anna Virginia ^a   Mantovani, Nicola ^a   Pilotto, Alberto ^c   Di Mario, Francesco ^a   Aragona, Giovanni ^a   Altavilla, Nadia ^a   Bertelè, Anna ^d   Borghi, Loris ^a  

^a UNIVERSITY OF PARMA   (Italy)

^b Endoscopical Unit   (Italy)

^c Geriatrics Unit   (Italy)

^d Endoscopical Unit   (Italy)

Author keywords

Antimicrobial activity; Lactoferrin; Modulation of immune system

Indexed keywords

IRON; IRON BINDING PROTEIN; LACTOFERRIN;

ANTIMICROBIAL ACTIVITY; BACTERIAL METABOLISM; BACTERICIDAL ACTIVITY; BACTERIOSTASIS; BINDING AFFINITY; DRUG ACTIVITY; DRUG MECHANISM; HOST RESISTANCE; IMMUNOMODULATION; IRON METABOLISM; MOLECULAR DYNAMICS; MONOCYTE; NEUTROPHIL; PROTEIN STRUCTURE; SHORT SURVEY; STRUCTURE ACTIVITY RELATION;

LACTOFERRIN;

EID: 0036998978     PISSN: 03924203     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Short Survey

References (22)

1. SOERENSEN M, SOERENSEN SPL. The protein in whey. C R Trav Lab Carlsberg 1939;23:55-99.
2. JOHANSSON BG. Isolation of an iron containing red protein from human milk. Acta Chem Scand 1960;14:510-2.
3. VORLAND LH. Lactoferrin-A multifunctional glycoprotein. APMIS 1999;107:971-981.
4. LEVAY PF, VILJOEN M. Lactoferrin-A general review. Haematologica 1995;80:252-267.
5. BAKER EN, ANDERSON BF, BAKER HM, HARIDAS M. JAMESON GB, NORRIS GE, RUMBALL SV, SMITH CA. Structure, function and flexibility of human lactoferrin. Int.J.Biol.Macromol. 1991;13:122-9.
6. BULLEN JJ, ROGERS HJ, GRIFFITHS E. Role of iron in bacterial infection. Curr Top Microbiol Immunol 1978;80:1-35.
7. BULLEN JJ. The significance of iron in infection. Rev Infect Dis 1981;3:1127-1138.
8. NEILANDS JB. Microbial envelope protein related to iron. Ann Int Microbiol. 1982;36:285-309.
9. OTTO BR, VERWEIJ VAN VUGT AMJJ, MACLAREN DM. Transferrins and heme-compounds as iron sources for pathogenic bacteria. Crit Rev Microbiol 1992;18:217-233.
10. ELLISON III RT. The effects of lactoferrin on gramnegative bacteria. Adv Exp Med Biol. 1994;357:71-90.
11. WADA T, AIBA Y, SHIMIZU K, TAKAGI A., MIWA T, KOGA Y. The therapeutic effect of bovine lactoferrin in the host infected with Helicobacter pylori. Scand J Gastroenterol. 1999;34:238-43.
12. TOMIDA M, BELLAMY W, TAKASE M, YAMAUCHI K, WAKABAYASHI H, KAWASE K. Potent antibacterial peptides generated by pepsin digestion of bovin lactoferrin. Journal of Diary Science. 1992;74:4137-4142.
13. ABRAHAM SN, SUN D, DALE JB, BEACHEY EH. Conservation of the D- mannose adhesion protein among type 1 fimbriated members of family Enterobacteriaceae. Nature 1988;366:682-4.
14. BELLAMY W, WAKABAYASHI H, TAKASE M, KAWASE K, SHIMAMURA S, TOMITA M. Killing of Candida albicans by lactoferricin B, a potent antimicrobial peptide derived from the N- terminal region of bovin lactoferrin. Med Microbiol Immunol 1993;182:97-105.
15. ISAMIDA T, TANAKA T, OMATA Y, YAMAUCHI K, SHIMAZAKI K, SAIKO A. Protective effect of lactoferricin against Toxoplasma gondii infection in mice. J Vet Med Sci 1998;60:241-4.
16. HARMSEN MC, SWART PJ, DE BETHUNE MP, PAUWELS R, DE CLERCQ E, The TH, Meijer DK. Antiviral effects of plasma and milk proteins: lactoferrin shows a potent activity against both human immunodeficiency virus and human cytomegalovirus in vitro. J Infect Dis 1995;172:380-88.
17. IKEDA M, SUGIYAMA K, TANAKA T, TANAKA K, SEKIHARA H, SHIMATOHNO K, KATO N. Lactoferrin markedly inhibits hepatitis C virus infection in cultured human hepatocytes. Biochem Biophys Res Commun 1998;245:549-53.
18. BAYNES RD, BEZWODA WR, KHAN Q, MANSOOR N. Relationship of plasma lactoferrin content to neutrophil regeneration and bone marrow infusion. Scand J Haematol 1986;36:79-84.
19. BRITIGAN BE, SERODY JS, COHEN MS. The role of lactoferrin as an anti-inflammatory molecule. Adv Exp Med Biol 1994;357:143-56.
20. BOXER LA, HAAK RA, YANG HH, WOLACH JB, WHITCOMB JA, BUTTERICK CJ, BAEHNER RL. Membrane bound lactoferrin alters the surface properties of polymorphonuclear leukocytes. J Clin Invest 1982;70:1049-57.
21. CROUCH SP, SLATER KJ, FLETCHER J. Regulation of cytochine release from nuclear cells by the iron binding protein lactoferrin. Blood 1992;80:235-40.
22. LEE GR. The anemia of chronic disease. Semin Hematol. 1983;20:61-80.