Deviation from additivity in mixture toxicity: Relevance of nonlinear dose-response relationships and cell line differences in genotoxicity assays with combinations of chemical mutagens and γ-radiation

Environmental Health Perspectives

Volumn 110, Issue SUPPL. 6, 2002, Pages 915-918

  Lutz, Werner K ^a   Vamvakas, Spyros ^a   Kopp Schneider, Annette ^b   Schlatter, Josef ^c   Stopper, Helga ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^c FEDERAL OFFICE OF PUBLIC HEALTH   (Switzerland)

Author keywords

137Cs; Ames test; Cell line; Chemically induced; Dose response relationship; Drug effects; Drug interactions; Ethyl methanesulfonate; Gamma rays; Genotoxicity; L5178Y; Micronuclei; Models; Mutagens; Polynuclear aromatic hydrocarbons; Radiation effects; Research design; Risk assessment; Statistics; TK6; WTK1

Indexed keywords

ANTHRACENE DERIVATIVE; BENZO[A]PYRENE; CESIUM 137; CHEMICAL MUTAGEN; DNA; MESYLIC ACID ETHYL ESTER;

AMES TEST; ANALYSIS OF VARIANCE; ANIMAL CELL; ANIMAL TISSUE; BIOASSAY; CELL DEATH; CELL LINE; CHEMICAL CARCINOGENESIS; CONTROLLED STUDY; CYTOTOXICITY; DETOXIFICATION; DNA REPAIR; DOSE RESPONSE; ENVIRONMENTAL EXPOSURE; GAMMA RADIATION; GENOTOXICITY; HUMAN; HUMAN CELL; IN VITRO STUDY; IONIZING RADIATION; LYMPHOMA CELL LINE; MOUSE; MUTAGEN TESTING; NONHUMAN; NONLINEAR SYSTEM; PILOT STUDY; POPULATION EXPOSURE; PRIORITY JOURNAL; RADIATION EXPOSURE; RAT; REVIEW; SALMONELLA TYPHIMURIUM; STATISTICAL ANALYSIS;

ANIMALIA; SALMONELLA TYPHIMURIUM;

EID: 0036995937     PISSN: 00916765     EISSN: None     Source Type: Journal    
DOI: 10.1289/ehp.02110s6915     Document Type: Review

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